Evidence map›Paper›PMID 16314432›Full record

ArticleThe Journal of cell biology2005

Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.

Meghan E Thorne, Cara J Gottardi

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Meghan E ThorneDepartment of Medicine, Northwestern University, Chicago, IL 60637, USA.
Cara J Gottardi
Northwestern University · US

Funding

Mechanism of nuclear signaling and cell-cell adhesion by cateninsR01GM076561 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOTTARDI, CARA J · 2006 to 2015
$2.8M
NIGMS NIH HHS R01 GM076561
6 · The paper itself

Abstract

Nuclear targeting of beta-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of beta-catenin. We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways.

Indexed as

Active Transport, Cell NucleusAnimalsbeta CateninCell NucleusDrosophila melanogasterEmbryo, NonmammalianExportin 1 ProteinKaryopherinsNuclear ProteinsNucleocytoplasmic Transport ProteinsPhosphorylationReceptors, Cytoplasmic and NuclearSignal TransductionWnt ProteinsXenopus laevisbeta CateninExportin 1 ProteinKaryopherinsNuclear ProteinsNucleocytoplasmic Transport ProteinsRANBP3 protein, humanReceptors, Cytoplasmic and NuclearWnt Proteins

Identifiers

PMID16314432
PMCPMC2171287
OpenAlexW2154964320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.