ArticleThe Journal of cell biology2005
Self-organization of an acentrosomal microtubule network at the basal cortex of polarized epithelial cells.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport.Molecular biology of the cell · 2018Article
- Microtubules and Microtubule-Associated Proteins.Cold Spring Harbor perspectives in biology · 2018Review
- Role of kinesins in directed adenovirus transport and cytoplasmic exploration.PLoS pathogens · 2018Article
- Regulation of long-distance transport of mitochondria along microtubules.Cellular and molecular life sciences : CMLS · 2018Review
- How selective severing by katanin promotes order in the plant cortical microtubule array.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.Journal of cell science · 2016Article
- Cytoskeletal Network Morphology Regulates Intracellular Transport Dynamics.Biophysical journal · 2015Article
- Memoryless self-reinforcing directionality in endosomal active transport within living cells.Nature materials · 2015Article
- Tir Is Essential for the Recruitment of Tks5 to Enteropathogenic Escherichia coli Pedestals.PloS one · 2015Article
- MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.Developmental biology · 2014Article
- Microtubule initiation from the nuclear surface controls cortical microtubule growth polarity and orientation in Arabidopsis thaliana.Plant & cell physiology · 2014Article
- Integrins and epithelial cell polarity.Journal of cell science · 2014Review
- The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells.International journal of cell biology · 2012Article
- Supported native plasma membranes as platforms for the reconstitution and visualization of endocytic membrane budding.Methods in cell biology · 2012Article
- Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta.The Journal of cell biology · 2010Article
- Delocalization of gamma-tubulin due to increased solubility in human breast cancer cell lines.Cancer biology & therapy · 2010Article
- Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cells.Molecular biology of the cell · 2009Article
- Article
- Role of APC and its binding partners in regulating microtubules in mitosis.Advances in experimental medicine and biology · 2009Review
- CLASP modulates microtubule-cortex interaction during self-organization of acentrosomal microtubules.Molecular biology of the cell · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms underlying the organization of centrosome-derived microtubule arrays are well understood, but less is known about how acentrosomal microtubule networks are formed. The basal cortex of polarized epithelial cells contains a microtubule network of mixed polarity. We examined how this network is organized by imaging microtubule dynamics in acentrosomal basal cytoplasts derived from these cells. We show that the steady-state microtubule network appears to form by a combination of microtubule-microtubule and microtubule-cortex interactions, both of which increase microtubule stability. We used computational modeling to determine whether these microtubule parameters are sufficient to generate a steady-state acentrosomal microtubule network. Microtubules undergoing dynamic instability without any stabilization points continuously remodel their organization without reaching a steady-state network. However, the addition of increased microtubule stabilization at microtubule-microtubule and microtubule-cortex interactions results in the rapid assembly of a steady-state microtubule network in silico that is remarkably similar to networks formed in situ. These results define minimal parameters for the self-organization of an acentrosomal microtubule network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.