ArticleMolecular biology of the cell2006
Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression.Journal of biomedical science · 2026Article
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.International journal of oral science · 2022Article
- Mammalian phospholipase D: Function, and therapeutics.Progress in lipid research · 2020Review
- Membrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells.Frontiers in cell and developmental biology · 2020Article
- Docosahexaenoic Acid (DHA) Induced Morphological Differentiation of Astrocytes Is Associated with Transcriptional Upregulation and Endocytosis of βMolecular neurobiology · 2019Article
- EGFR controls Drosophila tracheal tube elongation by intracellular trafficking regulation.PLoS genetics · 2017Article
- Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Clathrin-independent endocytosis: a cargo-centric view.Experimental cell research · 2013Review
- AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Endosomes derived from clathrin-independent endocytosis serve as precursors for endothelial lumen formation.PloS one · 2013Article
- Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7.British journal of pharmacology · 2012Article
- Cellular uptake mechanisms and endosomal trafficking of supercharged proteins.Chemistry & biology · 2012Article
- ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.The Journal of biological chemistry · 2011Article
- Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins.The Biochemical journal · 2011Article
- MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation.Molecular biology of the cell · 2011Article
- Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.Retrovirology · 2011Article
- A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.Nature cell biology · 2010Article
- The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.Traffic (Copenhagen, Denmark) · 2010Article
- Anthrax lethal toxin impairs CD1d-mediated antigen presentation by targeting the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.Infection and immunity · 2010Article
- ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.Current biology : CB · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Extracellular signal-regulated kinase (Erk) is widely recognized for its central role in cell proliferation and motility. Although previous work has shown that Erk is localized at endosomal compartments, no role for Erk in regulating endosomal trafficking has been demonstrated. Here, we report that Erk signaling regulates trafficking through the clathrin-independent, ADP-ribosylation factor 6 (Arf6) GTPase-regulated endosomal pathway. Inactivation of Erk induced by a variety of methods leads to a dramatic expansion of the Arf6 endosomal recycling compartment, and intracellular accumulation of cargo, such as class I major histocompatibility complex, within the expanded endosome. Treatment of cells with the mitogen-activated protein kinase kinase (MEK) inhibitor U0126 reduces surface expression of MHCI without affecting its rate of endocytosis, suggesting that inactivation of Erk perturbs recycling. Furthermore, under conditions where Erk activity is inhibited, a large cohort of Erk, MEK, and the Erk scaffold kinase suppressor of Ras 1 accumulates at the Arf6 recycling compartment. The requirement for Erk was highly specific for this endocytic pathway, because its inhibition had no effect on trafficking of cargo of the classical clathrin-dependent pathway. These studies reveal a previously unappreciated link of Erk signaling to organelle dynamics and endosomal trafficking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.