ArticleNucleic acids research2005
Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Reduced expression of Brain Expressed X-linked genes in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review.Journal of advanced research · 2026Review
- Ectopic expression of BEX genes in T-cell acute lymphoblastic leukemia.Blood advances · 2026Article
- LMO2 confers value as a potential immunotherapy marker in pan-cancer analysis and inhibits progression of Clear Cell Renal Cell Carcinoma.Translational oncology · 2025Article
- BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity.Oncogene · 2025Article
- MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature.American journal of human genetics · 2024Article
- Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells.Cell death & disease · 2023Article
- BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma.Cancer science · 2021Article
- Analyzing differentially expressed genes and pathways of Bex2-deficient mouse lung via RNA-Seq.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Article
- BEX2 promotes tumor proliferation in colorectal cancer.International journal of biological sciences · 2017Article
- Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition.Cell death & disease · 2016Article
- LMO2 at 25 years: a paradigm of chromosomal translocation proteins.Open biology · 2015Review
- Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs.PloS one · 2015Article
- Bex2 controls proliferation of human glioblastoma cells through NF-κB signaling pathway.Journal of molecular neuroscience : MN · 2014Article
- LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.Molecular biology reports · 2014Review
- Bex2 is critical for migration and invasion in malignant glioma cells.Journal of molecular neuroscience : MN · 2013Article
- Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2.Molecular and cellular endocrinology · 2011Article
- BEX2 has a functional interplay with c-Jun/JNK and p65/RelA in breast cancer.Molecular cancer · 2010Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Human Bex2 (brain expressed X-linked, hBex2) is highly expressed in the embryonic brain, but its function remains unknown. We have identified that LMO2, a LIM-domain containing transcriptional factor, specifically interacts with hBex2 but not with mouse Bex1 and Bex2. The interaction was confirmed both by pull-down with GST-hBex2 and by coimmunoprecipitation assays in vivo. Using electrophoretic mobility shift assay, we have demonstrated the physical interaction of hBex2 and LMO2 as part of a DNA-binding protein complex. We have also shown that hBex2 can enhance the transcriptional activity of LMO2 in vivo. Furthermore, using mammalian two-hybrid analysis, we have identified a neuronal bHLH protein, NSCL2, as a novel binding partner for LMO2. We then showed that LMO2 could up-regulate NSCL2-dependent transcriptional activity, and hBex2 augmented this effect. Thus, hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.