ArticleNucleic acids research2005
The excess of 5' introns in eukaryotic genomes.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Where the minor things are: a pan-eukaryotic survey suggests neutral processes may explain much of minor intron evolution.Nucleic acids research · 2023Article
- NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning.RNA (New York, N.Y.) · 2020Article
- Regional perturbation of gene transcription is associated with intrachromosomal rearrangements and gene fusion transcripts in high grade ovarian cancer.Scientific reports · 2019Article
- Architecture and Distribution of Introns in Core Genes of FourG3 (Bethesda, Md.) · 2017Article
- mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Evolution of the Exon-Intron Structure in Ciliate Genomes.PloS one · 2016Article
- Cis-acting signals modulate the efficiency of programmed DNA elimination in Paramecium tetraurelia.Nucleic acids research · 2015Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss.BMC biology · 2013Article
- Characterization of maltase clusters in the genus Drosophila.Journal of molecular evolution · 2011Article
- DNA double-strand break repair and the evolution of intron density.Trends in genetics : TIG · 2011Article
- Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts.Genome biology · 2010Article
- Regulation of transcription termination in the nematode Caenorhabditis elegans.Nucleic acids research · 2009Article
- Exon definition as a potential negative force against intron losses in evolution.Biology direct · 2008Article
- Article
- Spliceosomal introns as tools for genomic and evolutionary analysis.Nucleic acids research · 2008Review
- An overabundance of phase 0 introns immediately after the start codon in eukaryotic genes.BMC genomics · 2006Article
- Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number.Genome research · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, 21 completely sequenced eukaryotic genomes were analyzed using an intragene comparison approach. We found that all of these genomes show a significant 5'-biased distribution of introns of protein-coding genes. Our findings are different from previous studies based on the intergene method, where introns are biased towards the 5' end of genes only in intron-poor genomes, but are evenly distributed in intron-rich genomes. In addition, by analyzing the patterns of intron distribution of a set of well-compiled housekeeping genes from human and their respective orthologs identified by a bidirectional best BLAST hit method from the other genomes, we found that the trend of 5'-biased intron positions of the set of housekeeping genes for each genome is much more skewed than that of all genes of the same genome, and rarely if any of the housekeeping genes examined have an extremely 3'-biased position distribution in which all introns of a gene are located only at the 3' portion of the gene. The most parsimonious explanation for our findings may be the model in which intron loss is caused by homologous recombination between the genomic copy of a gene and a reverse transcriptase product of a spliced mRNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.