ArticleNucleic acids research2005
The genetic map and comparative analysis with the physical map of Trypanosoma brucei.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.PLoS pathogens · 2023Article
- The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice.Communications biology · 2021Article
- Reproduction in Trypanosomatids: Past and Present.Biology · 2021Review
- Article
- Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania.PLoS genetics · 2019Article
- Genetic Crosses and Linkage Mapping in Schistosome Parasites.Trends in parasitology · 2018Review
- The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense.PLoS neglected tropical diseases · 2017Article
- Population genomics reveals the origin and asexual evolution of human infective trypanosomes.eLife · 2016Article
- Null allele, allelic dropouts or rare sex detection in clonal organisms: simulations and application to real data sets of pathogenic microbes.Parasites & vectors · 2014Article
- Population genetics of Trypanosoma brucei circulating in Glossina palpalis palpalis and domestic animals of the Fontem sleeping sickness focus of Cameroon.Parasites & vectors · 2014Article
- Construction and analysis of high-density linkage map using high-throughput sequencing data.PloS one · 2014Article
- Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population.PLoS genetics · 2014Article
- Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci.PLoS neglected tropical diseases · 2013Article
- Article
- A sequence-anchored linkage map of the plant-parasitic nematode Meloidogyne hapla reveals exceptionally high genome-wide recombination.G3 (Bethesda, Md.) · 2012Article
- Parasite-driven pathogenesis in Trypanosoma brucei infections.Parasite immunology · 2011Review
- Population genetics of Trypanosoma evansi from camel in the Sudan.PLoS neglected tropical diseases · 2011Article
- "Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.PLoS pathogens · 2010Review
- An infectious topic in reticulate evolution: introgression and hybridization in animal parasites.Genes · 2010Article
- Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection.Infection and immunity · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and contributes to the debilitating disease 'Nagana' in cattle. To date we know little about the genes that determine drug resistance, host specificity, pathogenesis and virulence in these parasites. The availability of the complete genome sequence and the ability of the parasite to undergo genetic exchange have allowed genetic investigations into this parasite and here we report the first genetic map of T.brucei for the genome reference stock TREU 927, comprising of 182 markers and 11 major linkage groups, that correspond to the 11 previously identified chromosomes. The genetic map provides 90% probability of a marker being 11 cM from any given locus. Its comparison to the available physical map has revealed the average physical size of a recombination unit to be 15.6 Kb/cM. The genetic map coupled with the genome sequence and the ability to undertake crosses presents a new approach to identifying genes relevant to the disease and its prevention in this important pathogen through forward genetic analysis and positional cloning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.