ReviewJournal of anatomy2005
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies.
Review in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
214 citing papers in PubMed, 1 synthesis or guideline pooled it, 475 citations in OpenAlex.
- Developments in diagnostic and surgical techniques in children with sagittal suture craniosynostosis: a systematic review spanning the last 30 years.Orphanet journal of rare diseases · 2025Pooled it
- Calvarial Bloom Biomechanics: Dural Tension Governing Cranial Form.Clinical anatomy (New York, N.Y.) · 2026Review
- Dermal bone remodelling by invasive osteoblasts evolved in stem gnathostomes.bioRxiv : the preprint server for biology · 2026Article
- When Virchow's law fails: Crouzon syndrome as a test case for quantitative suture closure-endocranial shape relationships.Journal of anatomy · 2026Article
- The tectum transversum maintains patency of the developing coronal suture.Development (Cambridge, England) · 2026Article
- MEGF8 controls osteogenic differentiation through post-transcriptional regulation of BMP-SMAD signaling in craniosynostosis.Cell death and differentiation · 2026Article
- Initial In Vivo Analyses of Small Pore Polymer Scaffolds for Creation of an Artificial Cranial Stem Cell Niche.Bioengineering (Basel, Switzerland) · 2026Article
- Cerium-doped prussian blue nanozymes for bone regeneration and osteoprotection by Lhx2 in sutural distraction osteogenesis through multi-omics analysis.Journal of nanobiotechnology · 2026Article
- Generation of human induced pluripotent stem cell lines from patients with FGFR2-linked syndromic craniosynostosis.Disease models & mechanisms · 2025Article
- Inhibition of craniosynostosis and premature suture fusion inScience advances · 2025Article
- Clinical Approach to Cleft Lip and Palate with or Without Surgical Correction in Ten Brachycephalic Puppies.Veterinary sciences · 2025Article
- Non-syndromic craniosynostosis.Nature reviews. Disease primers · 2025Review
- Evolution of accessory bones in cetacean skull coupled with decreasing rate of ossification of cranial sutures.Scientific reports · 2025Article
- Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration.Stem cells (Dayton, Ohio) · 2025Review
- Investigation of Cranial Bone Changes Indicative of Increased Intracranial Pressure in Diverse Phenotypes of Craniosynostosis.Plastic and reconstructive surgery. Global open · 2025Article
- Divergent patterns of cranial suture fusion in marsupial and placental mammals.Zoological journal of the Linnean Society · 2025Article
- Concurrent myelomeningocele and sagittal craniosynostosis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A journey in the world of craniofacial development: From 1968 to the future.Journal of anatomy · 2024Review
- In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies.The Japanese dental science review · 2024Review
- Article
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian skull vault is constructed principally from five bones: the paired frontals and parietals, and the unpaired interparietal. These bones abut at sutures, where most growth of the skull vault takes place. Sutural growth involves maintenance of a population of proliferating osteoprogenitor cells which differentiate into bone matrix-secreting osteoblasts. Sustained function of the sutures as growth centres is essential for continuous expansion of the skull vault to accommodate the growing brain. Craniosynostosis, the premature fusion of the cranial sutures, occurs in 1 in 2500 children and often presents challenging clinical problems. Until a dozen years ago, little was known about the causes of craniosynostosis but the discovery of mutations in the MSX2, FGFR1, FGFR2, FGFR3, TWIST1 and EFNB1 genes in both syndromic and non-syndromic cases has led to considerable insights into the aetiology, classification and developmental pathology of these disorders. Investigations of the biological roles of these genes in cranial development and growth have been carried out in normal and mutant mice, elucidating their individual and interdependent roles in normal sutures and in sutures undergoing synostosis. Mouse studies have also revealed a significant correspondence between the neural crest-mesoderm boundary in the early embryonic head and the position of cranial sutures, suggesting roles for tissue interaction in suture formation, including initiation of the signalling system that characterizes the functionally active suture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.