ArticleImmunology2005
CD27+ B cells in human lymphatic organs: re-evaluating the splenic marginal zone.
Article in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Differences in mouse and human nonmemory B cell pools.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- B cells in human lymphoid structures.Clinical and experimental immunology · 2022Review
- Article
- Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.Mucosal immunology · 2021Review
- Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout life.The Journal of experimental medicine · 2021Article
- Contributions of Major Cell Populations to Sjögren's Syndrome.Journal of clinical medicine · 2020Review
- Plasma cells, plasmablasts, and AIDHistochemistry and cell biology · 2020Article
- Article
- Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity.Frontiers in immunology · 2019Article
- Human Extrafollicular CD4Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Capillary networks and follicular marginal zones in human spleens. Three-dimensional models based on immunostained serial sections.PloS one · 2018Article
- Human spleen microanatomy: why mice do not suffice.Immunology · 2015Review
- A new method for estimating species age supports the coexistence of malaria parasites and their Mammalian hosts.Molecular biology and evolution · 2015Article
- Article
- B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions.Histochemistry and cell biology · 2014Article
- Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond.BMC immunology · 2012Review
- The open microcirculation in human spleens: a three-dimensional approach.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- The follicular dendritic cell network in secondary follicles of human palatine tonsils and spleens.Histochemistry and cell biology · 2011Article
- beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection.Journal of virology · 2010Article
- CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection.The American journal of pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The marginal zone of human spleens is regarded as an organ-specific region harbouring sessile memory B cells. This opinion has arisen by extrapolating from results obtained in mice and rats. Detection of CD27(+) B cells in situ now revealed similarities among the most superficial region of B-cell follicles in human spleens, reactive lymph nodes, inflamed appendices, tonsils and terminal ilea. The follicular surface in these organs consists of small naïve immunoglobulin D (IgD)(+) CD27(-) B cells predominating in an inner area and larger IgD(+/-) CD27(+) B cells prevailing in a more superficial position. CD27(+) B cells may, however, also occupy the entire follicular periphery around the germinal centre. Together with additional peculiarities this distribution indicates a fundamental microanatomical difference among the human and rodent splenic white pulp. We hypothesize that the follicular periphery represents a recirculation compartment both for naïve and memory/natural reactive B cells in all human secondary lymphatic organs. This assumption implies a difference in recirculation behaviour among human and rodent B memory cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.