ArticleMolecular diversity2005
Molecular diversity of rat brain proteins as revealed by proteomic analysis.
Article in Molecular diversity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus.Current neuropharmacology · 2011Article
- Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain.Proteomics. Clinical applications · 2009Article
- Estradiol in vivo regulation of brain mitochondrial proteome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry.Genome research · 2007Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple protein expression forms (MPEFs) presenting splicing forms or co- and posttranslation modifications, account for the vast diversity, the myriad of gene products and clearly indicate problems which proteomics research is facing. In the present study, we generated a rat brain map representing MPEFs by the use of an analytical method based on two-dimensional electrophoresis combined with mass spectrometry. Forty-nine individual proteins were selected that showed more than two spots, resulting altogether into a total number of 357 expression forms. Some proteins showed large MPEFs numbers as e.g. tubulin alpha-1 chain (24 spots), ATP synthase alpha-chain (28), beta chain (17) or septin 7 (13). The molecular diversity observed in this map clearly shows that immunochemical or even protein chemical results from expressional studies have to be interpreted with caution, in particular if one dimensional electrophoretic or western blot techniques are applied and MPEFs are poorly resolved.
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