ArticleProceedings of the National Academy of Sciences of the United States of America1992
Cloning and chromosomal location of human alpha 1(XVI) collagen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Basic Structure, Physiology, and Biochemistry of Connective Tissues and Extracellular Matrix Collagens.Advances in experimental medicine and biology · 2021Article
- Minor collagens of the skin with not so minor functions.Journal of anatomy · 2019Review
- Collagens.Cell and tissue research · 2010Review
- Genome-wide search for microsatellite markers associated with radiologic alterations in the navicular bone of Hanoverian warmblood horses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- trans repression of the human metallothionein IIA gene promoter by PZ120, a novel 120-kilodalton zinc finger protein.Molecular and cellular biology · 1999Article
- Biochemical and immunohistochemical characterization of human type XIX defines a novel class of basement membrane zone collagens.The American journal of pathology · 1997Article
- hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Extraction and characterization of the tissue forms of collagen types II and IX from bovine vitreous.The Biochemical journal · 1994Article
- The complete intron/exon structure of Ephydatia mülleri fibrillar collagen gene suggests a mechanism for the evolution of an ancestral gene module.Journal of molecular evolution · 1993Article
- Characterization of an intronless collagen gene family in the marine sponge Microciona prolifera.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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5 authors.
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Abstract
We have characterized cDNA clones that encode a newly discovered collagenous polypeptide. A 4-kilobase (kb) cDNA clone was initially isolated by screening a human fibroblast cDNA library with a probe encoding the collagenous domain of the human alpha 3(VI) collagen. Subsequent screening of another fibroblast cDNA library yielded overlapping clones having a total length of 5.4 kb, which contained an open reading frame of 1603 amino acids including a 21-amino acid signal peptide. The predicted polypeptide consists of 10 collagenous domains 15-422 amino acids long, which were interspersed with 11 noncollagenous (NC) domains. Except for a large N-terminal NC11 domain of 312 residues, most of the NC domains were short (11-39 residues) and cysteine-rich. The overall structural arrangement differed significantly from other known collagen chains. Further analysis indicated that the deduced polypeptide exhibited several structural features characteristically seen in members of the fibril-associated collagen, types IX, XII, and XIV. In addition, the cysteine-rich motifs in the NC domains resembled those found in the cuticle collagen of Caenorhabditis elegans. Northern blot analyses showed hybridization of the cDNA to a 5.5-kb mRNA in human fibroblasts and keratinocytes. The gene was localized by in situ hybridization to band p34-35 of human chromosome 1. The data clearly support the conclusion that the cDNA encodes a collagen chain that has not been previously described. We suggest that the cDNA clones encode the alpha 1 chain of type XVI collagen.
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