ArticleEMBO reports2006
Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres.
Article in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Unwrap RAP1's Mystery at Kinetoplastid Telomeres.Biomolecules · 2024Review
- In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei.Nucleic acids research · 2021Article
- Review
- May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression.Frontiers in cell and developmental biology · 2021Review
- Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.Cell reports · 2020Article
- Escaping the immune system by DNA repair and recombination in African trypanosomes.Open biology · 2019Review
- VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Review
- Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.Cellular microbiology · 2013Review
- Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes.Nucleic acids research · 2013Article
- Telomere components as potential therapeutic targets for treating microbial pathogen infections.Frontiers in oncology · 2012Article
- NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.PLoS biology · 2012Article
- Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.Molecular and cellular biology · 2011Article
- NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei.Nucleic acids research · 2011Article
- Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.Current opinion in microbiology · 2010Review
- Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.Molecular microbiology · 2010Article
- Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.Nucleic acids research · 2010Article
- RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.Cell · 2009Article
- JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes.Nucleic acids research · 2009Article
- Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.Molecular microbiology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The African trypanosome, Trypanosoma brucei, is a flagellated pathogenic protozoan that branched early from the eukaryotic lineage. Unusually, it uses RNA polymerase I (Pol I) for mono-telomeric expression of variant surface glycoprotein (VSG) genes in bloodstream-form cells. Many other subtelomeric VSG genes are reversibly repressed, but no repressive DNA sequence has been identified in any trypanosomatid. Here, we show that artificially seeded de novo telomeres repress Pol I-dependent gene expression in mammalian bloodstream and insect life-cycle stages of T. brucei. In a telomeric VSG expression site, repression spreads further along the chromosome and this effect is specific to the bloodstream stage. We also show that de novo telomere extension is telomerase dependent and that the rate of extension correlates with the expression level of the adjacent gene. Our results show constitutive telomeric repression in T. brucei and indicate that an enhanced, developmental stage-specific repression mechanism controls antigenic variation.
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