ArticleProceedings of the National Academy of Sciences of the United States of America1992
Antiproliferative prostaglandins activate heat shock transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The trial behind it
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Who cites it
36 citing papers in PubMed, 179 citations in OpenAlex.
- Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.Cell stress & chaperones · 2024Review
- Hsf1 activation by proteotoxic stress requires concurrent protein synthesis.Molecular biology of the cell · 2021Article
- Prostaglandin A1 Decreases the Phosphorylation of Tau by Activating Protein Phosphatase 2A via a Michael Addition Mechanism at Cysteine 377.Molecular neurobiology · 2021Article
- Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies.Clinical science (London, England : 1979) · 2020Review
- Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction inFrontiers in molecular neuroscience · 2017Article
- Cardiac and hepatic role of r-AtHSP70: basal effects and protection against ischemic and sepsis conditions.Journal of cellular and molecular medicine · 2015Article
- The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Chemical research in toxicology · 2012Review
- The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.Molecular biology of the cell · 2012Article
- Protein homeostasis as a therapeutic target for diseases of protein conformation.Current topics in medicinal chemistry · 2012Review
- Small-molecule proteostasis regulators for protein conformational diseases.Nature chemical biology · 2011Article
- Article
- Protein homeostasis in models of aging and age-related conformational disease.Advances in experimental medicine and biology · 2010Review
- Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.Genes & development · 2008Review
- Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR.Nucleic acids research · 2007Article
- Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging.Journal of molecular neuroscience : MN · 2006Review
- Small molecule activators of the heat shock response and neuroprotection from stroke.Current atherosclerosis reports · 2004Review
- Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex.Journal of virology · 2004Article
- The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.British journal of pharmacology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Treatment of human K562 erythroleukemia cells with the antiproliferative prostaglandin A1 results in the elevated transcription of two heat shock genes, HSP70 and HSP90. Parallel with increased heat shock gene transcription is the activation of heat shock transcription factor. Heat shock transcription factor levels are induced within 60 min after prostaglandin A1 addition to levels similar to that achieved during heat shock. The requirement for protein synthesis for prostaglandin A1 activation of heat shock transcription factor suggests that effects on nascent protein synthesis may be involved in the signaling mechanism. Although it is unclear whether the activation of a heat shock response by prostaglandins is relevant to the biochemical properties of these natural substances, cells pretreated with prostaglandin A1 are protected against a subsequent heat shock, indicative of a thermotolerant state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.