ArticleProceedings of the National Academy of Sciences of the United States of America1992
The complete sequence of Drosophila beta-spectrin reveals supra-motifs comprising eight 106-residue segments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Generation and maintenance of apical rib-like actin fibers in epithelial support cells of the Drosophila eye.Development (Cambridge, England) · 2026Article
- Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion.Nature cell biology · 2018Article
- Spectrin-based skeleton as an actor in cell signaling.Cellular and molecular life sciences : CMLS · 2012Review
- Article
- Molecular epitopes of the ankyrin-spectrin interaction.Biochemistry · 2008Article
- Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.The Journal of cell biology · 2006Article
- Stabilities of folding of clustered, two-repeat fragments of spectrin reveal a potential hinge in the human erythroid spectrin tetramer.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.The Journal of cell biology · 2000Article
- Drosophila beta spectrin functions independently of alpha spectrin to polarize the Na,K ATPase in epithelial cells.The Journal of cell biology · 2000Article
- Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila.The Journal of cell biology · 1999Article
- Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia.The Journal of clinical investigation · 1997Article
- Interchain binding at the tail end of the Drosophila spectrin molecule.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster.The Journal of cell biology · 1993Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The alpha and beta chains of spectrin are homologous, yet they have acquired different structural features that work in synergy to give the multimer its overall properties. The primary amino acid sequence of each spectrin subunit is dominated by tandemly repeated 106-residue motifs. By comparing the complete Drosophila beta-spectrin sequence with other spectrins we have discovered evidence that a higher-order, 848-amino acid supra-motif is tandemly repeated in both alpha- and beta-spectrin. These data argue that alpha- and beta-spectrin, rather than evolving independently from sequences encoding the ancestral 106-residue motifs, must have arisen after the establishment of a large supra-motif composed of eight of the 106-residue motifs. Our data suggest the segment structure of a progenitor gene that gave rise to both alpha- and beta-spectrin as well as dystrophin. The structural differences that evolved after the split between the alpha- and beta-spectrin genes confer the independent functions that exist in their products today.
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