ArticleProceedings of the National Academy of Sciences of the United States of America1992
Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
85 citing papers in PubMed, 195 citations in OpenAlex.
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- Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice.The Journal of experimental medicine · 2022Article
- Single Cell Analysis of Bistable Expression of Pathogenicity Island 1 and the Flagellar Regulon inMicroorganisms · 2021Article
- One for All, but Not All for One: Social Behavior during Bacterial Diseases.Trends in microbiology · 2019Review
- Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis.Scientific reports · 2018Article
- Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion.Molecular & cellular proteomics : MCP · 2016Article
- Review
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- Salmonella enterica invasion of polarized epithelial cells is a highly cooperative effort.Infection and immunity · 2014Article
- Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells.Cancer research · 2013Article
- Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion.PLoS pathogens · 2012Article
- Exploration of chlamydial type III secretion system reconstitution in Escherichia coli.PloS one · 2012Article
- The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2011Article
- Bacterial effector-involved temporal and spatial regulation by hijack of the host ubiquitin pathway.Frontiers in microbiology · 2011Article
- Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels.Microbes and infection · 2009Article
- Development of multiple strain competitive index assays for Listeria monocytogenes using pIMC; a new site-specific integrative vector.BMC microbiology · 2008Article
- Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.PLoS pathogens · 2008Article
- An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells.Infection and immunity · 2007Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Penetration of intestinal epithelial cells is an important step in the pathogenesis of Salmonella infections. We have characterized a gene, invE, that is necessary for Salmonella invasion of cultured epithelial cells. The predicted amino acid sequence of InvE showed significant homology to the Yersinia outer membrane protein YopN (LcrE). Strains of Salmonella carrying mutations in invE were unable to penetrate Henle-407 human intestinal cells and Madin-Darby canine kidney cells, although they were fully capable of attaching to the same cells. Unlike wild-type Salmonella typhimurium, invE mutants failed to change the intracellular free calcium levels or the distribution of polymerized actin in cultured epithelial cells; neither did they alter the normal architecture of the microvilli of polarized Madin-Darby canine kidney cells. Wild-type S. typhimurium was able to rescue the invasive phenotype of the invE mutants in simultaneous infections of cultured epithelial cells although it did not rescue the Escherichia coli strain RDEC-1. We hypothesize that invE mutants are deficient in triggering the intracellular events that lead to bacterial internalization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.