ArticleFEBS letters2005
Adenovirus-mediated expression of the C-terminal domain of SARS-CoV spike protein is sufficient to induce apoptosis in Vero E6 cells.
Article in FEBS letters, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation.Journal of biomedical science · 2024Review
- Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications.Mitochondrion · 2023Review
- SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet Aggregation.Frontiers in immunology · 2022Article
- Review
- SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.Cell metabolism · 2021Article
- Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design.Viruses · 2021Review
- Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications.Frontiers in medicine · 2021Article
- Cell death signalling in virus infection.Cellular signalling · 2020Review
- The molecular virology of coronaviruses.The Journal of biological chemistry · 2020Review
- Review
- Modulation of Autophagy by SARS-CoV-2: A Potential Threat for Cardiovascular System.Frontiers in physiology · 2020Review
- Human Coronaviruses: A Review of Virus-Host Interactions.Diseases (Basel, Switzerland) · 2016Review
- A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform.Journal of virology · 2015Article
- Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice.Vaccine · 2014Article
- The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function.The international journal of biochemistry & cell biology · 2009Article
- Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation.Microbiology and molecular biology reviews : MMBR · 2008Review
- Article
- Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronaviruses.Cellular microbiology · 2007Review
- Severe acute respiratory syndrome coronavirus gene 7 products contribute to virus-induced apoptosis.Journal of virology · 2007Article
- Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus.Comparative immunology, microbiology and infectious diseases · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pro-apoptotic properties of severe acute respiratory syndrome coronavirus (SARS-CoV) structural proteins were studied in vitro. By monitoring apoptosis indicators including chromatin condensation, cellular DNA fragmentation and cell membrane asymmetry, we demonstrated that the adenovirus-mediated over-expression of SARS-CoV spike (S) protein and its C-terminal domain (S2) induce apoptosis in Vero E6 cells in a time- and dosage-dependent manner, whereas the expression of its N-terminal domain (S1) and other structural proteins, including envelope (E), membrane (M) and nucleocapsid (N) protein do not. These findings suggest a possible role of S and S2 protein in SARS-CoV induced apoptosis and the molecular pathogenesis of SARS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.