ArticleProceedings of the National Academy of Sciences of the United States of America1992
Identification of the major soluble cuticular glycoprotein of lymphatic filarial nematode parasites (gp29) as a secretory homolog of glutathione peroxidase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 103 citations in OpenAlex.
- Identification and characterization of epicuticular proteins of nematodes sharing motifs with cuticular proteins of arthropods.PloS one · 2022Article
- A rapid, parasite-dependent cellular response to Dirofilaria immitis in the Mongolian jird (Meriones unguiculatus).Parasites & vectors · 2021Article
- The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy.Frontiers in cellular and infection microbiology · 2021Review
- A Proteomic Analysis of the Body Wall, Digestive Tract, and Reproductive Tract of Brugia malayi.PLoS neglected tropical diseases · 2015Article
- Lymphatic filariasis: perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Virtual screening and in vitro assay of potential drug like inhibitors from spices against glutathione-S-transferase of filarial nematodes.Journal of molecular modeling · 2012Article
- Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets.PLoS neglected tropical diseases · 2011Article
- Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals.BMC evolutionary biology · 2009Article
- Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling.PLoS neglected tropical diseases · 2009Article
- Stage- and gender-specific proteomic analysis of Brugia malayi excretory-secretory products.PLoS neglected tropical diseases · 2008Article
- Translationally controlled tumor protein of Brugia malayi functions as an antioxidant protein.Parasitology research · 2007Article
- Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.Infection and immunity · 1998Article
- Cytostatic and cytotoxic effects of activated macrophages and nitric oxide donors on Brugia malayi.Infection and immunity · 1997Article
- Expression and characterization of glutathione peroxidase activity in the human blood fluke Schistosoma mansoni.Infection and immunity · 1996Article
- Characterization of the manganese superoxide dismutase cDNA and gene from the human parasite Onchocerca volvulus.The Biochemical journal · 1995Article
- Isolation and identification of a glutathione peroxidase homolog gene, gpxA, present in Neisseria meningitidis but absent in Neisseria gonorrhoeae.Infection and immunity · 1995Article
- Comparison of the patterns of codon usage and bias between Brugia, Echinococcus, Onchocerca and Schistosoma species.Parasitology research · 1995Article
- The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.The Journal of cell biology · 1994Article
- Extracellular and cytoplasmic CuZn superoxide dismutases from Brugia lymphatic filarial nematode parasites.Infection and immunity · 1994Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have cloned and identified the major cuticular glycoprotein (gp29) of lymphatic filarial nematode parasites as a homolog of the antioxidant enzyme glutathione peroxidase. The derived amino acid sequence predicted a protein of 25.8 kDa, with an amino-terminal hydrophobic signal peptide and two sites for N-linked glycosylation, consistent with the documented properties of gp29. Transcription of a full-length cDNA in an SP65 vector and subsequent translation of the RNA in reticulocyte lysates in vitro generated a protein of 27 kDa, which was glycosylated upon the addition of pancreatic microsomal membranes. A postulated role for this secreted enzyme could be inhibition of the oxidative burst of leukocytes and neutralization of secondary products of lipid peroxidation, thus providing one explanation for the resistance of these parasites to immune effector mechanisms and their persistence in the mammalian host.
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