ArticleBMC gastroenterology2005
Role of rapid urease test and histopathology in the diagnosis of Helicobacter pylori infection in a developing country.
Article in BMC gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 54 citations in OpenAlex.
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- Site-specific dental plaque pH in 13-year-old Thai schoolchildren.Clinical oral investigations · 2015Article
- Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes.World journal of gastroenterology · 2015Article
- Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection.World journal of gastroenterology · 2014Article
- Low rate of recurrence of Helicobacter pylori infection in spite of high clarithromycin resistance in Pakistan.BMC gastroenterology · 2013Article
- Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy.BMC gastroenterology · 2012Article
- Predictive value of neutrophil infiltration as a marker of Helicobacter pylori infection.World journal of gastroenterology · 2012Article
- Comparing Multiplex PCR and Rapid Urease Test in the Detection of H. pylori in Patients on Proton Pump Inhibitors.Gastroenterology research and practice · 2012Article
- Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors.World journal of gastroenterology · 2008Article
- The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs.Digestive diseases and sciences · 2008Article
- [Diagnostic Methods for the Detection ofActa gastroenterologica LatinoamericanaArticle
- Yogic gut aeration techniques to inhibit Helicobacter pylori-induced acid peptic diseases: A pilot randomized controlled trial.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the effect of commonly self-prescribed proton pump inhibitors (PPI) on the results of rapid urease test and histology for the diagnosis of H. pylori infection.
methodsOne hundred-nine consecutive patients with dyspeptic symptoms attending the endoscopy suite were enrolled in this study. Antrum biopsy specimens were collected at endoscopy for the rapid urease test (Pronto Dry, Medical Instrument Corp, France) and histopathology. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and like-hood ratio of a positive and negative of Pronto Dry test were compared against histology. The gold standard test for the diagnosis of H. pylori infection was histopathology.
resultsSixty-one percent (66/109) patients were males with mean age of 43 +/- 14.1 years and age range 17-80 years. Fifty-two percent (57/109) were not on any medications while 48% (52/109) used PPI before presentation to the outpatients. Pronto Dry was positive in 40% (44/109) and negative in 60% (65/109). Histopathology was positive for H. pylori in 57% (62/109) and negative in 43% (47/109). The sensitivity, specificity, PPV, NPV and like-hood ratio of a positive and negative Pronto Dry test with and without PPI were 43.3%, 86.4%, 81.3%, 3.18, 0.656 and 52.8% vs 71.9%, 80%, 82.1%, 69%, 3.59 and 0.35.
conclusionThis study shows that the sensitivity, specificity, NPV and PPV of rapid urease test was reduced in patients who are on PPI. The exclusive use of the rapid urease test for the diagnosis of Helicobacter pylori cannot be recommended in patients with prior PPI use.
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