ArticleThe Journal of physiology2006
Cholinergic control of excitability of spinal motoneurones in the salamander.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Cortical excitability in smoking and not smoking individuals with and without nicotine.Psychopharmacology · 2013Trial
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats.Scientific reports · 2022Article
- Acetylcholine and spinal locomotor networks: The insider.Physiological reports · 2021Review
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Spinal cholinergic interneurons differentially control motoneuron excitability and alter the locomotor network operational range.Scientific reports · 2018Article
- Homeostatic regulation through GABA and acetylcholine muscarinic receptors of motor trigeminal neurons following sleep deprivation.Brain structure & function · 2017Article
- The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair.Scientific reports · 2016Article
- The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus.Pflugers Archiv : European journal of physiology · 2015Review
- Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander.Neuroscience bulletin · 2013Review
- Muscarinic control of AMPA receptor responsiveness in mouse spinal cord motoneurons.The Journal of physiology · 2012Article
- Article
- Noradrenergic modulation of intrinsic and synaptic properties of lumbar motoneurons in the neonatal rat spinal cord.Frontiers in neural circuits · 2010Article
- Cellular and synaptic actions of acetylcholine in the lamprey spinal cord.Journal of neurophysiology · 2008Article
- Afterhyperpolarization time-course and minimal discharge rate in low threshold motor units in humans.Experimental brain research · 2008Article
- Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats.The Journal of physiology · 2006Article
- Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cholinergic modulation of the electrical properties of spinal motoneurones was investigated in vitro, with the use of the whole-cell patch-clamp recording technique in lumbar spinal cord slices from juvenile urodeles (Pleurodeles waltlii). Bath application of acetylcholine (20 microM) with eserine (20 microM) induced an increase in the resting membrane potential, a decrease of the input resistance, a decrease of the action potential amplitude, and a reduction of the medium afterhyperpolarization (mAHP) that followed each action potential. Moreover, the firing rate of motoneurones during a depolarizing current pulse and the slope of their stimulus current-spike frequency relation were increased. All of these effects were mimicked by extracellular application of muscarine (20 microM), and blocked by application of the muscarinic receptor antagonist atropine (0.1-1 microM). They were not observed during bath application of nicotine (10 microM). These results suggest that the cholinergic modulation of spinal motoneurone excitability was mediated by activation of muscarinic receptors. Our results further show that the muscarinic action primarily resulted from a reduction of the Ca2+-activated K+ current responsible for the mAHP, an inhibition of the hyperpolarization-activated cation current, Ih, and an enhancement of the inward rectifying K+ current, I(Kir). We conclude that cholinergic modulation can contribute significantly to the production of motor behaviour by altering several ionic conductances responsible for the repetitive discharge of motoneurones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.