ArticleDevelopment (Cambridge, England)2006
MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing.
Article in Development (Cambridge, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer's Disease BothFrontiers in neuroscience · 2022Article
- Large-Scale Annotation and Evolution Analysis of MiRNA in Insects.Genome biology and evolution · 2021Article
- Article
- Adult Muscle Formation RequiresGenetics · 2017Article
- Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain.Open biology · 2016Article
- Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells.Development (Cambridge, England) · 2014Article
- Stimulated nuclear import by β-like importins.F1000prime reports · 2013Review
- The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development.Molecules and cells · 2012Article
- MEK1 inhibits cardiac PPARα activity by direct interaction and prevents its nuclear localization.PloS one · 2012Article
- Article
- Moleskin is essential for the formation of the myotendinous junction in Drosophila.Developmental biology · 2011Article
- Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway.Cellular and molecular life sciences : CMLS · 2011Article
- Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.PloS one · 2011Article
- Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells.PloS one · 2010Article
- C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells.Developmental biology · 2008Article
- Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.Molecular biology of the cell · 2007Article
- Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development.Developmental biology · 2007Article
- Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mitogen-activated protein kinases (MAPKs) phosphorylate target proteins in both the cytoplasm and nucleus, and a strong correlation exists between the subcellular localization of MAPK and resulting cellular responses. It was thought that MAPK phosphorylation was always followed by rapid nuclear translocation. However, we and others have found that MAPK phosphorylation is not always sufficient for nuclear translocation in vivo. In the developing Drosophila wing, MAPK-mediated signaling is required both for patterning and for cell proliferation, although the mechanism of this differential control is not fully understood. Here, we show that phosphorylated MAPK (pMAPK) is held in the cytoplasm in differentiating larval and pupal wing vein cells, and we show that this cytoplasmic hold is required for vein cell fate. At the same time, we show that MAPK does move into the nucleus of other wing cells where it promotes cell proliferation. We propose a novel Ras pathway bifurcation in Drosophila and our results suggest a mechanism by which MAPK phosphorylation can signal two different cellular outcomes (differentiation versus proliferation) based on the subcellular localization of MAPK.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.