ArticlePediatric surgery international2006
Influence of the site of small bowel resection on intestinal epithelial cell apoptosis.
Article in Pediatric surgery international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- The effect of hepatocyte growth factor on intestinal adaption in an experimental model of short bowel syndrome.Pediatric surgery international · 2023Article
- Loss of Slfn3 induces a sex-dependent repair vulnerability after 50% bowel resection.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Dietary supplementation with vitamin D stimulates intestinal epithelial cell turnover after massive small bowel resection in rats.Pediatric surgery international · 2013Article
- p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Inhibition of ACE activity contributes to the intestinal structural compensation in a massive intestinal resection rat model.Pediatric surgery international · 2012Article
- Distraction-induced intestinal enterogenesis: preservation of intestinal function and lengthening after reimplantation into normal jejunum.Annals of surgery · 2012Article
- Proliferation analysis of the growth plate after diaphyseal midshaft fracture by 5'-bromo-2'-deoxy-uridine.Virchows Archiv : an international journal of pathology · 2010Article
- The role of angiotensin II type 1a receptor on intestinal epithelial cells following small bowel resection in a mouse model.Pediatric surgery international · 2008Article
- Modulation of mouse intestinal epithelial cell turnover in the absence of angiotensin converting enzyme.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection.Pediatric surgery international · 2007Article
- Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat.Pediatric surgery international · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Massive small bowel resection (SBR) results in a significant increase in intestinal epithelial cell (EC) proliferation as well as apoptosis. Because the site of SBR (proximal (P) vs. distal (D)) affects the degree of intestinal adaptation, we hypothesized that different rates of EC apoptosis would also be found between P-SBR and D-SBR models. Wild-type C57BL/6J mice underwent: (1) 60% P-SBR, (2) 60% D-SBR, or (3) SHAM-operation (transaction-reanastomosis) at the mid-gut point. Mice were sacrificed after 7 days. EC apoptosis was measured by TUNEL staining. EC-related apoptotic gene expression including intrinsic and extrinsic pathways was measured with reverse transcriptase-polymerase chain reaction. Bcl-2 and bax protein expression were analyzed by Western immunoblotting. Both models of SBR led to significant increases in villus height and crypt depth; however, the morphologic adaptation was significantly higher after P-SBR compared to D-SBR (P<0.01). Both models of SBR led to significant increases in enterocyte apoptotic rates compared to respective sham levels; however, apoptotic rates were 2.5-fold higher in ileal compared to jejunal segments (P<0.01). P-SBR led to significant increases in bax (pro-apoptotic) and Fas expression, whereas D-SBR resulted in a significant increase in TNF-alpha expression (P<0.01). EC apoptosis seems to be an important component of intestinal adaptation. The significant difference in EC apoptotic rates between proximal and distal intestinal segments appeared to be due to utilization of different mechanisms of action.
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Registered trials
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