ArticleJournal of pharmacokinetics and pharmacodynamics2005
The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach.
Article in Journal of pharmacokinetics and pharmacodynamics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2014Trial
- Pharmacokinetic analysis across studies to drive knowledge-integration: A tutorial on individual patient data meta-analysis (IPDMA).CPT: pharmacometrics & systems pharmacology · 2023Article
- Challenges faced when modeling clinical toxicology and toxinology events.CPT: pharmacometrics & systems pharmacology · 2022Article
- Reply to "Reflections on Aspirin Toxicity: Interpreting Effects of Sodium Bicarbonate and Activated Charcoal".Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2022Article
- Approaches to handling missing or "problematic" pharmacology data: Pharmacokinetics.CPT: pharmacometrics & systems pharmacology · 2021Article
- Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges.Frontiers in pharmacology · 2020Review
- The Use of Activated Charcoal to Treat Intoxications.Deutsches Arzteblatt international · 2019Review
- Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance.Therapeutic advances in psychopharmacology · 2019Review
- Fatal intoxication with antidepressants: a case with many culprits.Forensic science, medicine, and pathology · 2018Article
- The antipsychotic story: changes in prescriptions and overdose without better safety.British journal of clinical pharmacology · 2016Article
- The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors.Journal of pharmacokinetics and pharmacodynamics · 2016Article
- A novel approach for estimating ingested dose associated with paracetamol overdose.British journal of clinical pharmacology · 2016Article
- Activated charcoal for acute overdose: a reappraisal.British journal of clinical pharmacology · 2016Review
- The pharmacokinetics of sertraline in overdose and the effect of activated charcoal.British journal of clinical pharmacology · 2015Article
- Mirtazapine overdose is unlikely to cause major toxicity.Clinical toxicology (Philadelphia, Pa.) · 2014Observational
- Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.British journal of clinical pharmacology · 2013Article
- Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal.British journal of clinical pharmacology · 2012Article
- Mechanism-based pharmacodynamic modeling.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Activated charcoal for acute poisoning: one toxicologist's journey.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2010Review
- Electrocardiogram changes and arrhythmias in venlafaxine overdose.British journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defining the pharmacokinetics of drugs in overdose is complicated. Deliberate self-poisoning is generally impulsive and associated with poor accuracy in dose history. In addition, early blood samples are rarely collected to characterize the whole plasma-concentration time profile and the effect of decontamination on the pharmacokinetics is uncertain. The aim of this study was to explore a fully Bayesian methodology for population pharmacokinetic analysis of data that arose from deliberate self-poisoning with citalopram. Prior information on the pharmacokinetic parameters was elicited from 14 published studies on citalopram when taken in therapeutic doses. The data set included concentration-time data from 53 patients studied after 63 citalopram overdose events (dose range: 20-1700 mg). Activated charcoal was administered between 0.5 and 4 h after 17 overdose events. The clinical investigator graded the veracity of the patients' dosing history on a 5-point ordinal scale. Inclusion of informative priors stabilised the pharmacokinetic model and the population mean values could be estimated well. There were no indications of non-linear clearance after excessive doses. The final model included an estimated uncertainty of the dose amount which in a simulation study was shown to not affect the model's ability to characterise the effects of activated charcoal. The effect of activated charcoal on clearance and bioavailability was pronounced and resulted in a 72% increase and 22% decrease, respectively. These findings suggest charcoal administration is potentially beneficial after citalopram overdose. The methodology explored seems promising for exploring the dose-exposure relationship in the toxicological settings.
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