Evidence map›Paper›PMID 16306923›Full record

Trial reportEuropean journal of clinical nutrition2006

Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease.

A Michalsen, N Lehmann, C Pithan, N T M Knoblauch, S Moebus, F Kannenberg, L Binder, T Budde, G J Dobos

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 14 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 14 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Pooled it
  2. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
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  10. Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015
    Pooled it
  11. Guideline
  12. Pooled it
  13. Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2012
    Pooled it
  14. Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2011
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

A MichalsenDepartment of Internal Medicine V, Kliniken Essen-Mitte, University Duisburg-Essen, Germany. andreas.michalsen@uni-essen.de
N Lehmann
C Pithan
N T M Knoblauch
S Moebus
F Kannenberg
L Binder
T Budde
G J Dobos
Kliniken Essen-Mitte · DEZimmer Biomet (Germany) · DEAlfried Krupp Hospital · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMediterranean diet is associated with decreased levels of inflammatory markers and metabolic risk factors in epidemiologic studies and recent trials on patients with metabolic syndrome. Given the recent improvements in medical treatments, it is unclear if such beneficial effects are also present in patients with coronary artery disease (CAD). We therefore investigated the effect of Mediterranean diet on markers of inflammation and metabolic risk factors in patients with treated CAD.

designRandomized, controlled trial. SUBJECTS: A total of 101 patients (59.4+/-8.6 years, 23% female) with established and treated CAD (80% statins).

interventionsParticipants were assigned to a Mediterranean diet group (MG; n=48) with a 1-year program of 100 h of education, or to a written advice-only group (AG; n=53). Before and after intervention, we measured serum high-sensitivity C-reactive protein (hs-CRP), fibrinogen, fasting insulin, homocysteine, serum lipids and plasma fatty acids.

resultsThe Mediterranean diet program increased the intakes of fish, fruits/vegetables and moderately of canola/olive oil and increased plasma concentrations of long-chain n-3 polyunsaturated fatty acids in the MG. Median hs-CRP and mean fibrinogen, homocysteine, fasting insulin, triglycerides and serum cholesterols remained unchanged in both groups.

conclusionsAdoption of a Mediterranean diet by patients with medically treated CAD has no effect on markers of inflammation and metabolic risk factors. SPONSORSHIP: Alfried Krupp Foundation, Essen, Germany.

Indexed as

Diet, MediterraneanBiomarkersCoronary Artery DiseaseC-Reactive ProteinFatty AcidsFemaleFibrinogenHomocysteineHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInflammationInsulinLipidsMaleMiddle AgedRisk FactorsBiomarkersC-Reactive ProteinFatty AcidsFibrinogenHomocysteineHydroxymethylglutaryl-CoA Reductase InhibitorsInsulinLipids

Identifiers

PMID16306923
OpenAlexW2076446525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.