ArticleJournal of virology2005
Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- CD8Viral immunology · 2018Article
- Supranormal thymic output up to 2 decades after HIV-1 infection.AIDS (London, England) · 2016Article
- T cell response specificity and magnitude against SIVmac239 are not concordant in major histocompatibility complex-matched animals.Retrovirology · 2013Article
- Stochastic effects are important in intrahost HIV evolution even when viral loads are high.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.Journal of virology · 2012Article
- Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice.Science translational medicine · 2012Article
- Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.Journal of virology · 2012Article
- Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection.AIDS research and human retroviruses · 2012Article
- HIV-1 subtypes and recombinants in Northern Tanzania: distribution of viral quasispecies.PloS one · 2012Article
- Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response.Advances in virology · 2012Article
- Transcriptionally abundant major histocompatibility complex class I alleles are fundamental to nonhuman primate simian immunodeficiency virus-specific CD8+ T cell responses.Journal of virology · 2011Article
- Increasing CTL targeting of conserved sequences during early HIV-1 infection is correlated to decreasing viremia.AIDS research and human retroviruses · 2011Article
- HIV-1 infected monozygotic twins: a tale of two outcomes.BMC evolutionary biology · 2011Article
- Rapid T cell receptor delineation reveals clonal expansion limitation of the magnitude of the HIV-1-specific CD8+ T cell response.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.AIDS (London, England) · 2010Article
- MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.Science translational medicine · 2010Article
- Article
- Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccination.Journal of virology · 2008Article
- Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques.Genes and immunity · 2008Article
- Simian immunodeficiency virus SIVmac239 infection of major histocompatibility complex-identical cynomolgus macaques from Mauritius.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus type 1 (HIV-1) evolves in vivo under selective pressure from CD8+ T-lymphocyte (CTL) responses, which are in turn determined by host and viral genetic factors, such as restricting major histocompatibility complex molecules and the available viral epitope sequences. However, CTL are derived stochastically through the random gene rearrangements to produce T-cell receptors (TCR), and the relative impact of genetic versus stochastic processes on CTL targeting of HIV and immune-driven viral evolution is unclear. Here we evaluate identical twins infected with HIV-1 as neonates from a common blood transfusion, with subsequently similar environmental exposures, thereby allowing controlled comparisons of CTL targeting and viral evolution. Seventeen years after infection, their CTL targeting of HIV-1 was remarkably similar. In contrast, their overall TCR profiles were highly dissimilar, and a dominant epitope was recognized by distinctly different TCR in each twin. Furthermore, their viral epitopes had diverged, and there was ongoing viral phylogenetic divergence between the twins between 12 and 17 years after infection. These results indicate that while CTL targeting is predominately genetically determined, stochastic influences render the interaction of HIV-1 and host immunity, and therefore viral escape and CTL efficacy, unpredictable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.