ArticleJournal of virology2005
Contributions of matrix and large protein genes of the measles virus edmonston strain to growth in cultured cells as revealed by recombinant viruses.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Acute induction of IFNα is responsible for the attenuation of the live measles vaccine.bioRxiv : the preprint server for biology · 2025Article
- Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.mSphere · 2021Article
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- A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues.Science translational medicine · 2020Article
- Photocontrollable mononegaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evolutionary evidence for multi-host transmission of cetacean morbillivirus.Emerging microbes & infections · 2018Article
- Measles Vaccine.Viral immunology · 2018Review
- Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.Advances in virology · 2015Article
- Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.Journal of virology · 2013Article
- Cooperation between different RNA virus genomes produces a new phenotype.Nature communications · 2012Article
- The E89K Mutation in the Matrix Protein of the Measles Virus Affects In Vitro Cell Death and Virus Replication Efficiency in Human PBMC.The open virology journal · 2012Article
- The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity.Journal of virology · 2011Article
- In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques.Journal of virology · 2010Article
- Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild-type N, P, L genes on human renal cell carcinoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Adaptation of wild-type measles virus to cotton rat lung cells: E89K mutation in matrix protein contributes to its fitness.Virus genes · 2009Article
- Contribution of matrix, fusion, hemagglutinin, and large protein genes of the CAM-70 measles virus vaccine strain to efficient growth in chicken embryonic fibroblasts.Journal of virology · 2009Article
- Previously unrecognized amino acid substitutions in the hemagglutinin and fusion proteins of measles virus modulate cell-cell fusion, hemadsorption, virus growth, and penetration rate.Journal of virology · 2009Article
- Measles viruses possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM knock-in mice.Journal of virology · 2008Article
- Adaptation to cell culture induces functional differences in measles virus proteins.Virology journal · 2008Article
- Wild type measles virus attenuation independent of type I IFN.Virology journal · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Edmonston strain of measles virus (MV) was obtained by sequential passages of the original isolate in various cultured cells. Although attenuated in vivo, it grows efficiently in most primate cell lines. Previous studies have revealed that MV tropism cannot be solely explained by the use of CD150 and/or CD46 as a cellular receptor. In order to evaluate the contributions of individual genes of the Edmonston strain to growth in cultured cells, we generated a series of recombinant viruses in which part of the genome of the clinical isolate IC-B (which uses CD150 as a receptor) was replaced with the corresponding sequences of the Edmonston strain. The recombinant virus possessing the Edmonston hemagglutinin (H) gene (encoding the receptor-binding protein) grew as efficiently in Vero cells as the Edmonston strain. Those viruses having either the matrix (M) or large (L) protein gene from the Edmonston strain could also replicate well in Vero cells, although they entered them at low efficiencies. P64S and E89K substitutions were responsible for the ability of the M protein to make virus grow efficiently in Vero cells, while the first half of the Edmonston L gene was important for better replication. Despite efficient growth in Vero cells, the recombinant viruses with these mutations had growth disadvantage in CD150-positive lymphoid B95a cells. Thus, not only the H gene but also the M and L genes contribute to efficient replication of the Edmonston strain in some cultured cells.
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