ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Single synaptic vesicle tracking in individual hippocampal boutons at rest and during synaptic activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Optical Approaches to Dissect the Structure and Dynamics of the Synapse at Nanoscale Resolution.Advances in neurobiology · 2026Review
- Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles.Nature communications · 2024Article
- Nanoscale Organization of Vesicle Release at Central Synapses.Trends in neurosciences · 2019Review
- Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules.Nature protocols · 2017Article
- Activity-Dependence of Synaptic Vesicle Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses.eLife · 2017Article
- Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles.The Journal of cell biology · 2016Article
- Article
- Surface dynamics of voltage-gated ion channels.Channels (Austin, Tex.) · 2016Review
- Ultrastructural and functional fate of recycled vesicles in hippocampal synapses.Nature communications · 2015Article
- Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Synaptic vesicle recycling: steps and principles.The EMBO journal · 2014Review
- Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.Developmental neurobiology · 2012Article
- Dynamics of multiple trafficking behaviors of individual synaptic vesicles revealed by quantum-dot based presynaptic probe.PloS one · 2012Article
- Syntaxin1A lateral diffusion reveals transient and local SNARE interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- High- and low-mobility stages in the synaptic vesicle cycle.Biophysical journal · 2010Article
- Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction.BMC neuroscience · 2010Article
- Sharing vesicles between central presynaptic terminals: implications for synaptic function.Frontiers in synaptic neuroscience · 2010Article
- Synaptic vesicle pools: an update.Frontiers in synaptic neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How synaptic vesicles move within central nervous synapses to their docking sites at the plasma membrane is widely discussed in synaptic physiology. This question is especially difficult to investigate in the small hippocampal boutons, which themselves can slowly move during observation in primary cell culture. Here, we describe a single particle tracking method using dual fluorescent dye labels that enabled us to visualize the movements of a single vesicle and the respective synaptic bouton simultaneously during resting conditions and stimulation. We found vesicle mobility to be very low in the absence of stimulation, in line with previous studies. Interestingly, mobility was also found to be low during synaptic activity. We found that vesicles labeled preferentially via early, late, and spontaneous endocytotic mechanisms behaved similarly at rest and during stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.