ArticleChemical senses2006
A Drosophila nonvisual arrestin is required for the maintenance of olfactory sensitivity.
Article in Chemical senses, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Neofunctionalization of "Juvenile Hormone Esterase Duplication" in Drosophila as an odorant-degrading enzyme towards food odorants.Scientific reports · 2017Article
- Tick Haller's Organ, a New Paradigm for Arthropod Olfaction: How Ticks Differ from Insects.International journal of molecular sciences · 2017Article
- Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1.Genetics · 2013Article
- Modeling novelty habituation during exploratory activity in Drosophila.Behavioural processes · 2013Article
- The functional cycle of visual arrestins in photoreceptor cells.Progress in retinal and eye research · 2011Review
- Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells.PloS one · 2011Article
- The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila.PloS one · 2011Article
- Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.PLoS genetics · 2011Article
- β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development.The EMBO journal · 2010Article
- Distinct functions of acj6 splice forms in odor receptor gene choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.Developmental cell · 2009Review
- Functional characterization of kurtz, a Drosophila non-visual arrestin, reveals conservation of GPCR desensitization mechanisms.Insect biochemistry and molecular biology · 2008Article
- Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control.PloS one · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Nonvisual arrestins are a family of multifunctional adaptor molecules that regulate the activities of diverse families of receptors including G protein-coupled receptors, frizzled, and transforming growth factor-beta receptors. These activities indicate broad roles in both physiology and development for nonvisual arrestins. Drosophila melanogaster has a single nonvisual arrestin, kurtz, which is found at high levels within the adult olfactory receptor neurons (ORNs), suggesting a role for this gene in modulating olfactory sensitivity. Using heat-induced expression of a krz cDNA through development, we rescued krz(1) lethality. The resulting adults lacked detectable levels of krz in the olfactory system. The rescued krz(1) homozygotes have an incompletely penetrant antennal structural defect that was completely rescued by the neural expression of a krz cDNA. The krz(1) loss-of-function adults without visible antennal defects displayed diminished behavioral responsiveness to both aversive and attractive odors and also demonstrated reduced olfactory receptor potentials. Both the behavioral and electrophysiological phenotypes were rescued by the targeted expression of the krz cDNA within postdevelopmental ORNs. Thus, krz is required within the nervous system for antennal development and is required later in the ORNs for the maintenance of olfactory sensitivity in Drosophila. The reduced receptor potentials in krz(1) antenna indicate that nonvisual arrestins are required for the early odor-induced signaling events within the ORNs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.