ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2005
Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?Human reproduction updatePooled it
- A comprehensive review of the roles of T-cell immunity in preeclampsia.Frontiers in immunology · 2025Review
- Preeclampsia-Derived Exosomes Imbalance the Activity of Th17 and Treg in PBMCs from Healthy Pregnant Women.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The Distribution of Foxp3 and CD68 in Preeclamptic and Healthy Placentas: A Histomorphological Evaluation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.International journal of molecular sciences · 2022Article
- Cellular immune responses in the pathophysiology of preeclampsia.Journal of leukocyte biology · 2022Review
- Innate and Adaptive Immune Responses in HELLP Syndrome.Frontiers in immunology · 2020Review
- Regulatory T and T helper 17 cells: Their roles in preeclampsia.Journal of cellular physiology · 2018Review
- Preeclampsia: From Inflammation to Immunoregulation.Clinical medicine insights. Blood disorders · 2018Article
- The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.Mediators of inflammation · 2017Article
- Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.Journal of cellular and molecular medicine · 2016Article
- Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Increased serum levels of inflammatory mediators and low frequency of regulatory T cells in the peripheral blood of preeclamptic Mexican women.BioMed research international · 2014Article
- T cell behavior at the maternal-fetal interface.The International journal of developmental biology · 2014Review
- Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.Frontiers in immunology · 2014Review
- HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia.Frontiers in immunology · 2014Review
- Regulatory T cells and the immune pathogenesis of prenatal infection.Reproduction (Cambridge, England) · 2013Review
- Cytokines as key players in the pathophysiology of preeclampsia.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Review
- Regulatory T cells in preeclampsia: some answers, more questions?The American journal of pathology · 2012Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problemThe acceptance of the semi-allogeneic fetus within the maternal environment requires tolerance mechanisms not fully characterized yet. Normal pregnancy is known to be associated with a Th2 profile. Furthermore, regulatory T cells (Tregs) were proposed to regulate the Th2/Th1 balance at early stages of pregnancy. Treg may avoid the shift to a Th1 profile, thus preventing miscarriage. Accordingly, spontaneous abortion is characterized by a Th1 dominance and diminished levels of Treg. The major aim of the present work was to investigate if pre-eclampsia, a late immunological complication of pregnancy, is characterized by similar hallmarks. METHOD OF STUDY: We measured the surface antigens CD4, CD25, CD8 and CTLA4 in peripheral blood from patients suffering from pre-eclampsia (n = 8) and age-matched patients undergoing normal pregnancies (n = 9) by four-color flow cytometry.
resultsWe were not able to find any significant differences in the levels of CD4(+), CD25(+), CD8(+), CTLA4, CD4(+)/CD25(+), CD4(+)/CD25(bright), CD4(+)/CTLA4, CD25(+)/CTLA4, CD4(+)/CD25(+)/CTLA4, CD8(+)/CD25(+), CD8(+)/CTLA4 or CD8(+)/CD25(+)/CTLA4 cell subsets.
conclusionsOur data confirm comparable number of Tregs during pre-eclampsia and normal pregnancy in peripheral blood. Other regulatory mechanisms might be involved during late pregnancy.
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