ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2005
A review of trafficking and activation of uterine natural killer cells.
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy.International journal of molecular medicine · 2015Trial
- Metabolomic Analysis of Key Metabolites and Regulatory Mechanisms in the Transition of Uterine Receptivity in Water Buffalo (Metabolites · 2025Article
- The revolutionary role of placental derivatives in biomedical research.Bioactive materials · 2025Review
- The central role of natural killer cells in preeclampsia.Frontiers in immunology · 2023Review
- 17-Hydroxyprogesterone caproate improves T cells and NK cells in response to placental ischemia; new mechanisms of action for an old drug.Pregnancy hypertension · 2020Article
- Lectin histochemical analysis of uterine natural killer cells in normal, hydatidiform molar and invasive molar pregnancy.Oncology letters · 2018Article
- Homing receptor expression is deviated on CD56+ blood lymphocytes during pregnancy in Type 1 diabetic women.PloS one · 2015Article
- Oxygen modulates human decidual natural killer cell surface receptor expression and interactions with trophoblasts.Biology of reproduction · 2014Article
- Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature.The Journal of clinical investigation · 2014Article
- The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy.Frontiers in endocrinology · 2014Review
- Endocrine factors modulating immune responses in pregnancy.Frontiers in immunology · 2014Review
- Effects of heme oxygenase-1 on innate and adaptive immune responses promoting pregnancy success and allograft tolerance.Frontiers in pharmacology · 2014Review
- Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- Progesterone: the ultimate endometrial tumor suppressor.Trends in endocrinology and metabolism: TEM · 2011Review
- NK cells, autoantibodies, and immunologic infertility: a complex interplay.Clinical reviews in allergy & immunology · 2010Review
- Do molecular signals from the conceptus influence endometrium decidualization in rodents?Journal of experimental zoology. Part B, Molecular and developmental evolution · 2009Review
- Human uterine natural killer cells but not blood natural killer cells inhibit human immunodeficiency virus type 1 infection by secretion of CXCL12.Journal of virology · 2009Article
- Angiogenesis in implantation.Journal of assisted reproduction and genetics · 2007Review
- UNK cells: their role in tissue re-modelling and preeclampsia.Seminars in immunopathology · 2007Review
- Disturbances in placental immunology: ready for therapeutic interventions?Springer seminars in immunopathology · 2006Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
problemEnrichment of uterine natural killer (uNK) cells occurs during pregnancy in many species. However, functions of uNK cells and regulation of their uterine homing are not fully defined. In mice and women, uNK cells contribute to angiogenesis, a role reviewed here and now addressed in a mammal with an alternative placental type. METHODS OF STUDY: To address lymphocyte functions, RNA from murine or porcine endometrium and lymphocytes purified from endometrium were analyzed using real-time or reverse transcription PCR. To address homing potential, human blood CD56(+) lymphocytes were evaluated using both RNA and functional adhesion to endothelium presented under shear force in frozen sections of gestation day 7 C57Bl/6J implantation sites. Women were serially sampled over a menstrual cycle or a clinical preparatory cycle for embryo transfer.
resultsActivation of murine uNK cells is associated with much greater increases in transcription for Eomes than for T-bet (Tbx21). Lymphocytes from normal porcine implantation sites transcribe vascular endothelial growth factor, placental growth factor, interferon-gamma and hypoxia-inducible factor (HIF)-1alpha. In fertile women, increases in L-selectin- and alpha4-integrin-mediated interactions between CD56(+) cells and endothelium occur at luteinizing hormone (LH) surge (cycling women) to oocyte pick up or embryo transfer, then return to pre-LH levels.
conclusionsUterine lymphocytes may universally promote pregnancy-associated endometrial angiogenesis. Recruitment of uNK precursor cells from blood appears to occur in a window promoted by rising plasma estrogen and LH and limited by rising progesterone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.