ArticleThe Journal of comparative neurology2006
Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system.
Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Functional role of the enteric nervous system in poultry intestinal health and production.Poultry science · 2026Review
- Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.bioRxiv : the preprint server for biology · 2024Article
- Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk.Journal of clinical medicine · 2019Review
- Somatostatin as an Active Substance in the Mammalian Enteric Nervous System.International journal of molecular sciences · 2019Review
- Involvement of Corticotropin-Releasing Factor and Receptors in Immune Cells in Irritable Bowel Syndrome.Frontiers in endocrinology · 2018Review
- Endogenous CRF in rat large intestine mediates motor and secretory responses to stress.Neurogastroenterology and motility · 2016Article
- Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress.Frontiers in neuroscience · 2014Review
- Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: down-regulation in ulcerative colitis.World journal of gastroenterology · 2013Article
- Neurogenic mucosal bicarbonate secretion in guinea pig duodenum.British journal of pharmacology · 2013Article
- Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.PloS one · 2012Article
- Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract.Frontiers in neuroscience · 2011Article
- Lipopolysaccharide increases plasma levels of corticotropin-releasing hormone in rats.Neuroendocrinology · 2011Article
- Corticotropin-releasing factor signaling and visceral response to stress.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Corticotropin releasing factor in the rat colon: expression, localization and upregulation by endotoxin.Peptides · 2010Article
- Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon.British journal of pharmacology · 2010Article
- Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors.Brain, behavior, and immunity · 2010Review
- Adrenergic stimulation mediates visceral hypersensitivity to colorectal distension following heterotypic chronic stress.Gastroenterology · 2010Article
- Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications.Journal of physiology and pharmacology : an official journal of the Polish Physiological Society · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Immunofluorescence was used to study immunoreactivity (IR) for corticotropin-releasing factor (CRF) in the guinea pig enteric nervous system. CRF-IR was expressed in both the myenteric and the submucosal plexuses of all regions of the large and small intestine and the myenteric plexus of the stomach. CRF-IR nerve fibers were present in the myenteric and submucosal plexuses, in the circular muscle coat, and surrounding submucosal arterioles. Most of the CRF-IR fibers persisted in the myenteric and submucosal plexuses after 7 days in organotypic culture. CRF-IR was not coexpressed with tyrosine hydroxylase-IR or calcitonin gene-related peptide-IR fibers. The proportions of CRF-IR cell bodies in the myenteric plexus increased progressively from the stomach (0.6%) to the distal colon (2.8%). Most of the CRF-IR myenteric neurons (95%) had uniaxonal morphology; the remainder had Dogiel type II multipolar morphology. CRF-IR cell bodies in the myenteric plexus of the ileum expressed IR for choline acetyltransferase (56.9%), substance P (55.0%), and nitric oxide synthase (37.9%). CRF-IR never colocalized with IR for calbindin, calretinin, neuropeptide Y, serotonin, or somatostatin in the myenteric plexus. CRF-IR cell bodies were more abundant in the submucosal plexus (29.9-38.0%) than in the myenteric plexus. All CRF-IR neurons in submucosal ganglia expressed vasoactive intestinal peptide-IR and were likely to be secretomotor/vasodilator neurons. CRF-IR neurons did not express IR for the CRF(1) receptor. CRF(1)-IR was expressed in neuronal neighbors of those with CRF-IR. Collective evidence suggests that VIPergic secretomotor neurons might provide synaptic input to neighboring cholinergic neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.