ArticleMolecular and cellular biology1992
The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Tunable cell differentiation via reprogrammed mating-type switching.Nature communications · 2024Article
- Interspecies variation reveals a conserved repressor of alpha-specific genes in Saccharomyces yeasts.Genes & development · 2008Article
- Mating types and sexual development in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 1997Review
- Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations.Molecular and cellular biology · 1997Article
- ST-1, a 39-kilodalton protein in Trypanosoma brucei, exhibits a dual affinity for the duplex form of the 29-base-pair subtelomeric repeat and its C-rich strand.Molecular and cellular biology · 1995Article
- A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter.Nucleic acids research · 1994Article
- MCM1 point mutants deficient in expression of alpha-specific genes: residues important for interaction with alpha 1.Molecular and cellular biology · 1994Article
- A library of yeast genomic MCM1 binding sites contains genes involved in cell cycle control, cell wall and membrane structure, and metabolism.Molecular and cellular biology · 1994Article
- Transcription of alpha-specific genes in Saccharomyces cerevisiae: DNA sequence requirements for activity of the coregulator alpha 1.Molecular and cellular biology · 1993Article
- Saccharomyces cerevisiae BUF protein binds to sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation.Molecular and cellular biology · 1993Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The yeast cell type regulator alpha 1 cooperates with a constitutive factor, MCM1 protein, to recognize the promoter and activate transcription of several alpha-specific genes. I show here that the alpha 1 and MCM1 proteins bind specifically to one of the two strands of their recognition sequence. This single-strand-binding activity shares several characteristics with the duplex-binding properties of these proteins: (i) the MCM1 protein binds alone to single-stranded and duplex sequences of both the alpha-specific (P'Q) and a-specific (P) binding sites; (ii) the alpha 1 protein requires both the MCM1 protein and the Q sequence to bind either single-stranded or duplex DNA; (iii) the alpha 1 protein stimulates binding of the MCM1 protein to both single-stranded and duplex DNAs; and (iv) the affinities of the proteins for single-stranded and duplex DNAs are comparable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.