ArticleCurrent biology : CB2005
A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Article in Current biology : CB, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 118 citations in OpenAlex.
- Article
- Mug20-Rec25-Rec27 binds DNA and enhances meiotic DNA break formation via phase-separated condensates.Nucleic acids research · 2025Article
- Antifungal activity and mechanism ofFrontiers in microbiology · 2025Article
- A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Membrane and organelle rearrangement during ascospore formation in budding yeast.Microbiology and molecular biology reviews : MMBR · 2024Review
- The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence.Nucleic acids research · 2024Article
- A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture.Current biology : CB · 2024Article
- A DRP-like pseudoenzyme coordinates with MICOS to promote cristae architecture.bioRxiv : the preprint server for biology · 2023Article
- Article
- Meiotic chromosome organization and its role in recombination and cancer.Current topics in developmental biology · 2023Review
- Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast.PLoS genetics · 2022Article
- Dynamic configurations of meiotic DNA-break hotspot determinant proteins.Journal of cell science · 2022Article
- Reciprocal best structure hits: using AlphaFold models to discover distant homologues.Bioinformatics advances · 2022Article
- OsPRD2 is essential for double-strand break formation, but not spindle assembly during rice meiosis.Frontiers in plant science · 2022Article
- Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.Current genetics · 2021Article
- Article
- Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast.Journal of cell science · 2021Article
- Article
- Atypical meiosis can be adaptive in outcrossedeLife · 2020Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
13 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Meiosis is a specialized form of cell division by which sexually reproducing diploid organisms generate haploid gametes. During a long prophase, telomeres cluster into the bouquet configuration to aid chromosome pairing, and DNA replication is followed by high levels of recombination between homologous chromosomes (homologs). This recombination is important for the reductional segregation of homologs at the first meiotic division; without further replication, a second meiotic division yields haploid nuclei. In the fission yeast Schizosaccharomyces pombe, we have deleted 175 meiotically upregulated genes and found seven genes not previously reported to be critical for meiotic events. Three mutants (rec24, rec25, and rec27) had strongly reduced meiosis-specific DNA double-strand breakage and recombination. One mutant (tht2) was deficient in karyogamy, and two (bqt1 and bqt2) were deficient in telomere clustering, explaining their defects in recombination and segregation. The moa1 mutant was delayed in premeiotic S phase progression and nuclear divisions. Further analysis of these mutants will help elucidate the complex machinery governing the special behavior of meiotic chromosomes.
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