ArticleThe Biochemical journal2006
L-cysteate sulpho-lyase, a widespread pyridoxal 5'-phosphate-coupled desulphonative enzyme purified from Silicibacter pomeroyi DSS-3(T).
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Bacterial sulfoquinovose cycling across aquatic ecosystems.FEMS microbiology reviews · 2026Review
- Correlation analysis between key volatile compounds and core functional bacterial community during Sichuan black tea processing.Food chemistry: X · 2024Article
- Enantioselective transformation of phytoplankton-derived dihydroxypropanesulfonate by marine bacteria.The ISME journal · 2024Article
- Oxygenolytic sulfoquinovose degradation by an iron-dependent alkanesulfonate dioxygenase.iScience · 2023Article
- Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut.Nature communications · 2023Article
- Sulfoquinovose is a widespread organosulfur substrate for Roseobacter clade bacteria in the ocean.The ISME journal · 2023Article
- Sulfur metabolites in the pelagic ocean.Nature reviews. Microbiology · 2019Review
- Sulfonate-based networks between eukaryotic phytoplankton and heterotrophic bacteria in the surface ocean.Nature microbiology · 2019Article
- Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.Scientific reports · 2018Article
- Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With HFrontiers in microbiology · 2018Article
- Bacterial transcriptome remodeling during sequential co-culture with a marine dinoflagellate and diatom.The ISME journal · 2017Article
- Entner-Doudoroff pathway for sulfoquinovose degradation in Pseudomonas putida SQ1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- An Updated genome annotation for the model marine bacterium Ruegeria pomeroyi DSS-3.Standards in genomic sciences · 2014Article
- Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.Journal of bacteriology · 2013Article
- Gene clusters involved in isethionate degradation by terrestrial and marine bacteria.Applied and environmental microbiology · 2010Article
- Homotaurine metabolized to 3-sulfopropanoate in Cupriavidus necator H16: enzymes and genes in a patchwork pathway.Journal of bacteriology · 2009Article
- Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase.Journal of bacteriology · 2009Article
- Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria.Journal of bacteriology · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative utilization of L-cysteate (2-amino-3-sulphopropionate) as the sole source of carbon and energy for growth of the aerobic, marine bacterium Silicibacter pomeroyi DSS-3(T) was observed. The sulphonate moiety was recovered in the medium largely as sulphite, and the appropriate amount of the ammonium ion was also observed. Genes [suyAB (3-sulpholactate sulpho-lyase)] encoding the known desulphonation reaction in cysteate degradation were absent from the genome, but a homologue of a putative sulphate exporter gene (suyZ) was found, and its neighbour, annotated as a D-cysteine desulphhydrase, was postulated to encode pyridoxal 5'-phosphate-coupled L-cysteate sulpho-lyase (CuyA), a novel enzyme. Inducible CuyA was detected in cysteate-grown cells. The enzyme released equimolar pyruvate, sulphite and the ammonium ion from L-cysteate and was purified to homogeneity by anion-exchange, hydrophobic-interaction and gel-filtration chromatography. The N-terminal amino acid sequence of this 39-kDa subunit confirmed the identification of the cuyA gene. The native enzyme was soluble and homomultimeric. The K(m)-value for L-cysteate was high (11.7 mM) and the enzyme also catalysed the D-cysteine desulphhydrase reaction. The gene cuyZ, encoding the putative sulphite exporter, was co-transcribed with cuyA. Sulphite was exported despite the presence of a ferricyanide-coupled sulphite dehydrogenase. CuyA was found in many bacteria that utilize cysteate.
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