ArticleMolecular psychiatry2006
Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?Molecular neurobiology · 2025Review
- Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer's Disease BothFrontiers in neuroscience · 2022Article
- Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders.Molecular psychiatry · 2021Review
- Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.The Biochemical journal · 2020Review
- Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.Neurobiology of disease · 2019Review
- Unraveling the genes implicated in Alzheimer's disease.Biomedical reports · 2017Article
- A novel ALS-associated variant ineLife · 2017Article
- The ubiquilin gene family: evolutionary patterns and functional insights.BMC evolutionary biology · 2014Article
- Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.Neuropathology : official journal of the Japanese Society of Neuropathology · 2014Article
- Ubiquilin 2 is not associated with tau pathology.PloS one · 2013Article
- A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease.Neurobiology of aging · 2012Article
- Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.The Journal of biological chemistry · 2011Article
- Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Alzheimer's disease and tauopathy studies in flies and worms.Neurobiology of disease · 2010Review
- A Likelihood-Based Approach for Missing Genotype Data.Human heredity · 2010Article
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.Molecular psychiatry · 2009Article
- Effects of ubiquilin 1 on the unfolded protein response.Journal of molecular neuroscience : MN · 2009Article
- APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging.Annual review of clinical psychology · 2009Review
- Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.Archives of neurology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The gene coding for ubiquilin 1 (UBQLN1) is located near a linkage peak on chromosome 9q22.2 and it also impacts the function of presenilin proteins involved in early-onset Alzheimer's disease (AD). Recently, genetic variation in UBQLN1 has been shown to affect the risk of AD in two independent family-based samples. The purpose of this study was to confirm the reported association in a large case-control sample and to also examine the association of UBQLN1 SNPs with quantitative measures of AD progression, namely age-at-onset (AAO), disease duration and Mini-Mental State Examination (MMSE) score. We examined the associations of three SNPs in the UBQLN1 gene (intron 6/A>C, intron 8/T>C and intron 9/A>G) in up to 978 LOAD cases and 808 controls. All SNPs were in significant linkage disequilibrium (P<0.0001). While modest significant associations were observed in the single-site regression analysis, 3-site haplotype analysis revealed significant associations (P<0.0001 for overall haplotype analysis). One common haplotype (H4) defined by intron 6/A-intron 8/C-intron 9/G alleles was associated with AD risk and one less common haplotype (H5) defined by intron 6/C-intron 8/C-intron 9/A alleles was associated with protection. The adjusted odds ratios with potentially one and two copies of risk haplotype H4 were 1.5 (95% CI: 0.99-2.26; P=0.054) and 3.66 (95% CI: 1.43-9.39; P=0.007), respectively, and odds ratio for haplotype H5 carriers was 0.31 (95% CI: 0.10-0.95; P=0.0398). In addition to disease risk, the homozygosity of the risk haplotype was also associated with older AAO, longer disease duration and lower MMSE score. In summary, our data from a large case-control cohort indicate that genetic variation in the UBQLN1 gene has a modest effect on risk, AAO and disease duration of AD. Our haplotype data suggest the presence of additional putative functional variants either in the UBQLN1 gene or nearby genes and provide strong justification for additional work in this region on chromosome 9.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.