ArticleThe Journal of experimental medicine2005
Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
104 citing papers in PubMed, 177 citations in OpenAlex.
- Innate-like Gene Expression of Lung-Resident Memory CD8American journal of respiratory and critical care medicine · 2021Trial
- Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens.Nature immunology · 2026Article
- Neonatal CD19Frontiers in immunology · 2026Article
- Tissue-resident immune cells: from defining characteristics to roles in diseases.Signal transduction and targeted therapy · 2025Review
- An intranasal combination vaccine induces systemic and mucosal immunity against COVID-19 and influenza.NPJ vaccines · 2024Article
- Nanoparticle technology for mRNA: Delivery strategy, clinical application and developmental landscape.Theranostics · 2024Review
- Tissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation.Clinical and experimental immunology · 2023Review
- CD8 T cell response and its released cytokine IFN-γ are necessary for lung alveolar epithelial repair during bacterial pneumonia.Frontiers in immunology · 2023Article
- SpecificFrontiers in immunology · 2023Article
- Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.Science immunology · 2022Article
- Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19.Human vaccines & immunotherapeutics · 2022Article
- Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and Sequelae.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Review
- Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study.BMC medicine · 2022Article
- Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19.Clinical immunology (Orlando, Fla.) · 2022Article
- Tissue resident memory T cells in the respiratory tract.Mucosal immunology · 2022Review
- Human mucosal tissue-resident memory T cells in health and disease.Mucosal immunology · 2022Review
- Pulmonary resident memory T cells in respiratory virus infection and their inspiration on therapeutic strategies.Frontiers in immunology · 2022Review
- Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19.Frontiers in immunology · 2022Review
- Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity.Frontiers in immunology · 2022Review
- Reactive oxygen species associated immunoregulation post influenza virus infection.Frontiers in immunology · 2022Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lungs are frequently challenged by viruses, and resident CD8(+) T cells likely contribute to the surveillance of these pathogens. To obtain insight into local T cell immunity to respiratory viruses in humans, we determined the specificity, phenotype, and function of lung-residing CD8(+) T cells and peripheral blood CD8(+) T cells in a paired analysis. The lung contained markedly higher frequencies of influenza (FLU)-specific and respiratory syncytial virus (RSV)-specific CD8(+) T cells when compared with the circulation. This contrasted with an equal distribution of cytomegalovirus- and Epstein-Bar virus-specific CD8(+) T cells. Noticeably, a substantial fraction of the lung-residing FLU- and RSV-specific CD8(+) T cells had progressed to a relatively late differentiation phenotype, reflected by low expression of CD28 and CD27. Lung-derived FLU-specific CD8(+) T cells had low activation requirements, as expansion of these cells could be initiated by cognate peptide in the absence of helper cell-derived signals. Thus, the human lung contains high numbers of differentiated FLU- and RSV-specific memory CD8(+) T cells that can readily expand upon reexposure to virus. Resident lung T cells may provide immediate immunological protection against pulmonary virus infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.