ArticleJournal of immunology (Baltimore, Md. : 1950)2005
Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.
Article in Journal of immunology (Baltimore, Md. : 1950), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Complement and T cell activation in transplantation.Transplantation reviews (Orlando, Fla.) · 2025Review
- Complement: Functions, location and implications.Immunology · 2023Review
- Multiple CD59 Polymorphisms in Chinese Patients withJournal of immunology research · 2023Article
- CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity.Cancer immunology research · 2022Article
- Article
- Monocyte biology conserved across species: Functional insights from cattle.Frontiers in immunology · 2022Article
- Overexpression of Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains induces cluster of differentiation 59-mediated apoptosis in Jurkat cells.Experimental and therapeutic medicine · 2018Article
- Intracellular complement - the complosome - in immune cell regulation.Molecular immunology · 2017Review
- Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation.Frontiers in immunology · 2017Article
- Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.Human genomics · 2016Review
- Article
- The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease.Autoimmune diseases · 2014Review
- Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Depletion of complement does not impact initiation of xenobiotic-induced autoimmune disease.Immunology · 2012Article
- Complement factor C7 contributes to lung immunopathology caused by Mycobacterium tuberculosis.Clinical & developmental immunology · 2012Article
- The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Complement and viral pathogenesis.Virology · 2011Review
- The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review.International journal of inflammation · 2010Article
- Role and mechanism of action of complement in regulating T cell immunity.Molecular immunology · 2010Review
- Vaccinia virus-specific molecular signature in atopic dermatitis skin.The Journal of allergy and clinical immunology · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- mice compared with WT mice. Similarly, Cd59a-/- T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.