ArticleRNA (New York, N.Y.)2006
Conformational changes involved in initiation of minus-strand synthesis of a virus-associated RNA.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
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- A local, interactive network of 3' RNA elements supports translation and replication of Turnip crinkle virus.Journal of virology · 2012Article
- Hsp90 interacts specifically with viral RNA and differentially regulates replication initiation of Bamboo mosaic virus and associated satellite RNA.PLoS pathogens · 2012Article
- Multifaceted regulation of translational readthrough by RNA replication elements in a tombusvirus.PLoS pathogens · 2011Article
- Evolution of a helper virus-derived, ribosome binding translational enhancer in an untranslated satellite RNA of Turnip crinkle virus.Virology · 2011Article
- RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase.The Journal of biological chemistry · 2011Article
- A balance between circular and linear forms of the dengue virus genome is crucial for viral replication.RNA (New York, N.Y.) · 2010Article
- Interplay of RNA elements in the dengue virus 5' and 3' ends required for viral RNA replication.Journal of virology · 2010Article
- Satellite RNAs and Satellite Viruses of Plants.Viruses · 2009Article
- Genome cyclization as strategy for flavivirus RNA replication.Virus research · 2009Review
- Structural plasticity and rapid evolution in a viral RNA revealed by in vivo genetic selection.Journal of virology · 2009Article
- The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits.RNA (New York, N.Y.) · 2008Article
- A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replication.RNA (New York, N.Y.) · 2008Article
- Structural domains within the 3' untranslated region of Turnip crinkle virus.Journal of virology · 2008Article
- Long-distance RNA-RNA interactions between terminal elements and the same subset of internal elements on the potato virus X genome mediate minus- and plus-strand RNA synthesis.RNA (New York, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Synthesis of wild-type levels of turnip crinkle virus (TCV)-associated satC complementary strands by purified, recombinant TCV RNA-dependent RNA polymerase (RdRp) in vitro was previously determined to require 3' end pairing to the large symmetrical internal loop of a phylogenetically conserved hairpin (H5) located upstream from the hairpin core promoter. However, wild-type satC transcripts, which fold into a single detectable conformation in vitro as determined by temperature-gradient gel electrophoresis, do not contain either the phylogenetically inferred H5 structure or the 3' end/H5 interaction. This implies that conformational changes are required to produce the phylogenetically inferred H5 structure for its pairing with the 3' end, which takes place subsequent to the initial conformation assumed by the RNA and prior to transcription initiation. The DR region, located 140 nucleotides upstream from the 3' end and previously determined to be important for transcription in vitro and replication in vivo, is proposed to have a role in the conformational switch, since stabilizing the phylogenetically inferred H5 structure decreases the negative effects of a DR mutation in vivo. In addition, high levels of aberrant transcription correlate with a specific conformational change in the Pr while maintaining the same conformation of the 3' terminus. These results suggest that a series of events that promote conformational changes is needed to expose the 3' terminus to the RdRp for accurate synthesis of wild-type levels of complementary strands in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.