ArticleThe Journal of cell biology2005
Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 59 citations in OpenAlex.
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Endocannabinoids produced in photoreceptor cells in response to light activateScience signaling · 2022Article
- Article
- PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.PLoS genetics · 2020Article
- Cucurbitacin B Activates Bitter-Sensing Gustatory Receptor Neurons via Gustatory Receptor 33a inMolecules and cells · 2020Article
- Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity inThe Journal of biological chemistry · 2020Article
- Rapid Release of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice.Cell death and differentiation · 2020Article
- Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2.The Journal of biological chemistry · 2019Article
- Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The V-ATPase V1 subunit A1 is required for rhodopsin anterograde trafficking in Drosophila.Molecular biology of the cell · 2018Article
- A Single Residue Mutation in the GαG3 (Bethesda, Md.) · 2018Article
- The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site.Channels (Austin, Tex.) · 2017Article
- The Phosphorylation State of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.PLoS biology · 2015Article
- Coordination and fine motor control depend on Drosophila TRPγ.Nature communications · 2015Article
- Article
- Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.The Journal of biological chemistry · 2014Article
- Food experience-induced taste desensitization modulated by the Drosophila TRPL channel.Nature neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila transient receptor potential (TRP) serves dual roles as a cation channel and as a molecular anchor for the PDZ protein, INAD (inactivation no afterpotential D). Null mutations in trp cause impairment of visual transduction, mislocalization of INAD, and retinal degeneration. However, the impact of specifically altering TRP channel function is not known because existing loss-of-function alleles greatly reduce protein expression. In the current study we describe the isolation of a set of new trp alleles, including trp(14) with an amino acid substitution juxtaposed to the TRP domain. The trp(14) flies stably express TRP and display normal molecular anchoring, but defective channel function. Elimination of the anchoring function alone in trp(Delta)(1272), had minor effects on retinal morphology whereas disruption of channel function caused profound light-induced cell death. This retinal degeneration was greatly suppressed by elimination of the Na(+)/Ca(2+) exchanger, CalX, indicating that the cell death was due primarily to deficient Ca(2+) entry rather than disruption of the TRP-anchoring function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.