ArticleThe Journal of cell biology2005
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance.iScience · 2024Article
- High-fat diet aggravates prenatal low-dose DEHP exposure induced spermatogenesis disorder: Characterization of testicular metabolic patterns in mouse offspring.Chemosphere · 2022Article
- What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?Frontiers in endocrinology · 2022Review
- Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation.The American journal of pathology · 2020Article
- Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Frontiers in cell and developmental biology · 2018Review
- Article
- Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.PLoS genetics · 2015Article
- Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.Biochimica et biophysica acta · 2013Review
- Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.Biochemistry and analytical biochemistry : current research · 2012Article
- Targeting the regulatory machinery of BIM for cancer therapy.Critical reviews in eukaryotic gene expression · 2012Article
- Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.The Journal of biological chemistry · 2011Article
- Indispensable roles of mammalian Cbl family proteins as negative regulators of protein tyrosine kinase signaling: Insights from in vivo models.Communicative & integrative biology · 2011Article
- The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.The Journal of clinical investigation · 2009Article
- c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.Molecular biology of the cell · 2009Article
- Cbl negatively regulates JNK activation and cell death.Cell research · 2009Article
- The role of the ubiquitin proteasome system in ischemia and ischemic tolerance.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2009Review
- betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.Molecular cell · 2009Article
- Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim.Cell cycle (Georgetown, Tex.) · 2009Review
- Mutant B-RAF mediates resistance to anoikis via Bad and Bim.Oncogene · 2008Article
- c-Cbl is not required for ERK1/2-dependent degradation of BimEL.Cellular signalling · 2007Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proto-oncoprotein Cbl is known to control several signaling processes. It is highly expressed in the testis, and because spermatogenesis is androgen dependent, we investigated the androgen dependency expression of Cbl through its testicular sub-localization and its expression levels in rats that were exposed to the antiandrogen flutamide or were hypophysectomized. We report the androgen dependency of Cbl as it localizes in pachytene spermatocytes during androgen-dependent stages, is down-regulated upon flutamide exposure, and is up-regulated with testosterone in hypophysectomized rats. Coculture experiments showed the key control exerted by the Sertoli cell on Cbl activity. As flutamide induces germ cell apoptosis, we investigate members of the Bcl-2 family upon flutamide exposure. We show that the proapoptotic Bcl-2 family member Bim mirrored Cbl expression through a posttranscriptional process. We also show that in Cbl knockout mouse testes, the imbalance between the high expression of Bim and Smac/Diablo and anti-apoptotic factors such as cellular inhibitor of apoptosis 2 favors a survival process, which makes these mice unresponsive to androgen withdrawal and could explain their hypofertility.
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Registered trials
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