ArticleNeuron2005
Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism.
Article in Neuron, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 93 citations in OpenAlex.
- Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- Earliest Experience of a Relatively Rare Sound But Not a Frequent Sound Causes Long-Term Changes in the Adult Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.Nature neuroscience · 2020Article
- Article
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.Nature communications · 2017Article
- Proteome dynamics during postnatal mouse corpus callosum development.Scientific reports · 2017Article
- A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.PloS one · 2017Article
- EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.The Journal of comparative neurology · 2016Article
- EphA7 regulates spiral ganglion innervation of cochlear hair cells.Developmental neurobiology · 2016Article
- Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.Neuroscience bulletin · 2014Article
- Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.Neuron · 2014Article
- EphA7 signaling guides cortical dendritic development and spine maturation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Parcellation of the thalamus into distinct nuclei reflects EphA expression and function.Gene expression patterns : GEP · 2013Article
- 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.Cerebral cortex (New York, N.Y. : 1991) · 2013Review
- Retinal input regulates the timing of corticogeniculate innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Molecular mechanisms generating the topographic organization of corticothalamic (CT) circuits, which comprise more than three-quarters of the synaptic inputs onto sensory relay neurons, and their interdependence with thalamocortical (TC) axon development are unknown. Using in utero electroporation-mediated gene transfer, we show that EphA7-mediated signaling on neocortical axons controls the within-nucleus topography of CT projections in the thalamus. Notably, CT axons that mis-express EphA7 do not shift the relative positioning of their pathway within the subcortical telencephalon (ST), indicating that they do not depend upon EphA7/ephrin-A signaling in the ST for establishing this topography. Moreover, mis-expression of cortical EphA7 results in disrupted topography of CT projections, but unchanged inter- and intra-areal topography of TC projections. Our results support a model in which EphA/ephrin-A signaling controls independently the precision with which CT and TC projections develop, yet is essential for establishing their topographic reciprocity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.