ArticleBMC gastroenterology2005
Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine.
Article in BMC gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effect of preoperative single-dose corticosteroid administration on postoperative morbidity following esophagectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Pooled it
- Investigation of gastrointestinal injury-related biomarkers in dairy cattle with displaced abomasum.Veterinary medicine and science · 2023Article
- The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response.Cell reports · 2022Article
- CD36 maintains the gastric mucosa and associates with gastric disease.Communications biology · 2021Article
- Role of Leptin in the Digestive System.Frontiers in pharmacology · 2021Review
- A comparative study of the antioxidant and intestinal protective effects of extracts from different parts of Java tea (Food science & nutrition · 2018Article
- Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats.Balkan medical journal · 2016Article
- Effects of Leptin on Intestinal Ischemia-Reperfusion Injury.The Indian journal of surgery · 2015Article
- Effect of leptin and apelin preconditioning on hepatic ischemia reperfusion injury in rats.The Indian journal of surgery · 2014Article
- Remifentanil ameliorates intestinal ischemia-reperfusion injury.BMC gastroenterology · 2013Article
- Effect of αlipoic acid and silymarin on bladder outlet obstruction.Experimental and therapeutic medicine · 2013Article
- Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice.World journal of gastroenterology · 2012Article
- Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study.Experimental and therapeutic medicine · 2012Article
- Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Review
- Unraveling the link between leptin, ghrelin and different types of colitis.Annals of gastroenterology · 2011Review
- Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats.Nutrition & metabolism · 2010Article
- Somatostatin limits intestinal ischemia-reperfusion injury in macaques via suppression of TLR4-NF-kappaB cytokine pathway.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- The effect of leptin on intestinal recovery following ischemia-reperfusion injury in a rat.Pediatric surgery international · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe small intestine is extremely sensitive to ischemia-reperfusion (I/R) injury and a range of microcirculatory disturbances which contribute to tissue damage. Previous studies have shown that leptin plays an important physiological role in the microvasculature. The aim of this study was to evaluate the protective effects of leptin in I/R--induced mucosal injury in the small intestine.
methodsForty rats were divided into 5 groups (n = 8). Group I was subjected to a sham operation. Following mesenteric ischemia in group II (control); physiologic saline 1 cm3, in group III; leptin 100 microg/kg, and physiologic saline 1 cm3, in group IV; NG-L-arginine methyl ester (L-NAME) 20 mg/kg, and physiologic saline 1 cm3, in group V; leptin 100 microg/kg, L-NAME 20 mg/kg, and physiologic saline 1 cm3 were given intra-peritoneally. In these groups, an I/R procedure was performed by occlusion of the superior mesenteric artery for 45 min followed by 120 min reperfusion. After reperfusion, the small intestines were resected for malondialdehyde (MDA) and nitric oxide (NO) concentration and histopathologic properties. Mucosal lesions were scored between 0 and 5. Tissue MDA and NO concentration and histopathologic grades were compared statistically.
resultsTissue MDA level significantly increased (P < 0.05), tissue NO level significantly decreased in group V animals, compared to group III animals respectively (P < 0.001). Histopathologically, intestinal injury significantly decreased in the leptin treated ischemic group.
conclusionLeptin can be used safely in mesenteric occlusive diseases, since it induces NO formation and release in mesenteric vessels.
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