ArticleBMC evolutionary biology2005
Phylogenetic analyses suggest reverse splicing spread of group I introns in fungal ribosomal DNA.
Article in BMC evolutionary biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 47 citations in OpenAlex.
- Exploring the Potential and Advancements of Circular RNA Therapeutics.Exploration (Beijing, China) · 2025Review
- IMA fungus · 2025Article
- Accurate, comprehensive database of group I introns and their homing endonucleases.Bioinformatics advances · 2025Article
- Antagonistic conflict between transposon-encoded introns and guide RNAs.Science (New York, N.Y.) · 2024Article
- Insights into Fungal Mitochondrial Genomes and Inheritance Based on Current Findings from Yeast-like Fungi.Journal of fungi (Basel, Switzerland) · 2024Review
- Group I introns: Structure, splicing and their applications in medical mycology.Genetics and molecular biology · 2024Article
- Rediscovering a Forgotten System of Symbiosis: Historical Perspective and Future Potential.Genes · 2020Review
- Putative group I introns in the eukaryote nuclear internal transcribed spacers.Current genetics · 2020Article
- Polymorphism in Mitochondrial Group I Introns amongFrontiers in microbiology · 2018Article
- Accurate Estimation of Fungal Diversity and Abundance through Improved Lineage-Specific Primers Optimized for Illumina Amplicon Sequencing.Applied and environmental microbiology · 2016Article
- The diversity of mtDNA rns introns among strains of Ophiostoma piliferum, Ophiostoma pluriannulatum and related species.SpringerPlus · 2016Article
- "Cryptic" group-I introns in the nuclear SSU-rRNA gene of Verticillium dahliae.Current genetics · 2014Article
- Horizontal transfer and gene conversion as an important driving force in shaping the landscape of mitochondrial introns.G3 (Bethesda, Md.) · 2014Article
- Bacterial group I introns: mobile RNA catalysts.Mobile DNA · 2014Article
- Two-gene phylogeny of bright-spored Myxomycetes (slime moulds, superorder Lucisporidia).PloS one · 2013Article
- Group I introns and inteins: disparate origins but convergent parasitic strategies.Journal of bacteriology · 2009Review
- Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes.The EMBO journal · 2008Article
- Variability of nuclear SSU-rDNA group introns within Septoria species: incongruence with host sequence phylogenies.Journal of molecular evolution · 2007Article
- Patterns of group I intron presence in nuclear SSU rDNA of the Lichen family Parmeliaceae.Journal of molecular evolution · 2007Article
- Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans.Eukaryotic cell · 2006Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGroup I introns have spread into over 90 different sites in nuclear ribosomal DNA (rDNA) with greater than 1700 introns reported in these genes. These ribozymes generally spread through endonuclease-mediated intron homing. Another putative pathway is reverse splicing whereby a free group I intron inserts into a homologous or heterologous RNA through complementary base-pairing between the intron and exon RNA. Reverse-transcription of the RNA followed by general recombination results in intron spread. Here we used phylogenetics to test for reverse splicing spread in a taxonomically broadly sampled data set of fungal group I introns including 9 putatively ancient group I introns in the rDNA of the yeast-like symbiont Symbiotaphrina buchneri.
resultsOur analyses reveal a complex evolutionary history of the fungal introns with many cases of vertical inheritance (putatively for the 9 introns in S. buchneri) and intron lateral transfer. There are several examples in which introns, many of which are still present in S. buchneri, may have spread through reverse splicing into heterologous rDNA sites. If the S. buchneri introns are ancient as we postulate, then group I intron loss was widespread in fungal rDNA evolution.
conclusionOn the basis of these results, we suggest that the extensive distribution of fungal group I introns is at least partially explained by the reverse splicing movement of existing introns into ectopic rDNA sites.
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