ArticleEndocrine pathology2005
Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation.
Article in Endocrine pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature.Pituitary · 2017Pooled it
- Double PitNETs: A Case Report and Literature Review.Cancers · 2025Review
- Plurihormonal Pituitary Neuroendocrine Tumors: Clinical Relevance of Immunohistochemical Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- The hallmarks of cancer… in pituitary tumors?Reviews in endocrine & metabolic disorders · 2023Review
- Article
- CHST7 Methylation Status Related to the Proliferation and Differentiation of Pituitary Adenomas.Cells · 2022Article
- Overview of the 2022 WHO Classification of Pituitary Tumors.Endocrine pathology · 2022Review
- Structure, Function, and Morphology in the Classification of Pituitary Neuroendocrine Tumors: the Importance of Routine Analysis of Pituitary Transcription Factors.Endocrine pathology · 2020Article
- Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases.Diagnostic pathology · 2020Article
- Double pituitary adenomas in a large surgical series.Pituitary · 2019Article
- Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.Endocrine pathology · 2018Article
- Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature.Oncology letters · 2016Article
- Multiple Pituitary Adenomas: A Systematic Review.Frontiers in endocrinology · 2016Review
- Resistant prolactinoma: Is it monoclonal or polyclonal?Indian journal of endocrinology and metabolism · 2013Article
- Double, synchronous pituitary adenomas causing acromegaly and Cushing's disease. A case report and review of literature.Endocrine pathology · 2013Review
- A double pituitary adenoma presenting as a prolactin-secreting tumor with partial response to medical therapy. Case report.Endocrine pathology · 2010Article
- Prevalence of double pituitary adenomas in a surgical series: Clinical, histological and genetic features.Journal of endocrinological investigation · 2010Article
- The MEN1 gene and pituitary tumours.Hormone research · 2009Review
- Silent familial isolated pituitary adenomas: histopathological and clinical case report.Endocrine pathology · 2008Article
- Complex endocrinopathies in MEN-1: diagnostic dilemmas in endocrine oncology.Endocrine pathology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of double adenomas of the pituitary can be very complex and is usually suspected on histological assessment of a specimen and confirmed by immunohistochemical and ultrastructural studies. The most commonly applied technique is currently immunohistochemical staining to localize the six pituitary hormones. Application of this technique may fail to identify double adenomas when hormone immunoreactivity is weak or absent in one or both cell populations. We examined specimens from eight patients diagnosed with double adenomas over a 15-yr period. We tested the ability to detect the difference in the two adenomas in each case using three immunostains for the pituitary transcription factors Pit-1, T-pit, and SF-1. We conclude that immunohistochemical localization of the transcription factors Pit-1, T-pit, and SF-1 accurately detects and classifies the distinct cytodifferentiation of double adenomas of the pituitary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.