ArticleGenetics2006
High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 21 citations in OpenAlex.
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- Identification of genes functionally involved in the detrimental effects of mutant histone H3.3-K27M in Drosophila melanogaster.Neuro-oncology · 2019Article
- Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns.BMC genomics · 2015Article
- Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.Development (Cambridge, England) · 2014Article
- Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis.Development (Cambridge, England) · 2013Article
- Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance.PLoS genetics · 2010Article
- Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development.Chromosoma · 2010Article
- Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila.Alcoholism, clinical and experimental research · 2010Article
- The multi-AT-hook chromosomal protein of Drosophila melanogaster, D1, is dispensable for viability.Genetics · 2009Article
- Recent origins of sperm genes in Drosophila.Molecular biology and evolution · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many pleiotropic roles have been ascribed to small abundant HMG-Box (HMGB) proteins in higher eukaryotes but their precise function has remained enigmatic. To investigate their function genetically we have generated a defined deficiency uncovering the functionally redundant genes encoding HMGD and HMGZ, the Drosophila counterparts of HMGB1-3 in mammals. The resulting mutant is a strong hypomorphic allele of HmgD/Z. Surprisingly this allele is viable and exhibits only minor morphological defects even when homozygous. However, this allele interacts strongly with mutants of the Brahma chromatin remodeling complex, while no interaction was observed with mutant alleles of other remodeling complexes. We also observe genetic interactions between the HmgD/Z deficiency and some, but not all, known Brahma targets. These include the homeotic genes Sex combs reduced and Antennapedia, as well as the gene encoding the cell-signaling protein Rhomboid. In contrast to more general structural roles previously suggested for these proteins, we infer that a major function of the abundant HMGB proteins in Drosophila is to participate in Brahma-dependent chromatin remodeling at a specific subset of Brahma-dependent promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.