ArticleInfection and immunity2005
An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Early life infection withGut microbes · 2025Article
- Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8Mucosal immunology · 2024Article
- Article
- A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4BMC veterinary research · 2023Article
- Early immune and host cell responses toFrontiers in parasitology · 2023Article
- Evaluation of a vaccine candidate isolated fromVeterinary world · 2022Article
- Dual Transcriptomics To Determine Gamma Interferon-Independent Host Response to Intestinal Cryptosporidium parvum Infection.Infection and immunity · 2022Article
- Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium.Mucosal immunology · 2022Article
- The intestinal parasiteProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.Cellular and molecular gastroenterology and hepatology · 2019Article
- Lessons Learned from Protective Immune Responses to Optimize Vaccines against Cryptosporidiosis.Pathogens (Basel, Switzerland) · 2017Review
- Differences in innate IFNγ and IL-17 responses to Bordetella pertussis between BALB/c and C57BL/6 mice: role of γδT cells, NK cells, and dendritic cells.Immunologic research · 2017Article
- Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model.PLoS neglected tropical diseases · 2016Article
- Prospects for immunotherapy and vaccines against Cryptosporidium.Human vaccines & immunotherapeutics · 2014Review
- The cell biology of cryptosporidium infection.Microbes and infection · 2011Review
- CD4+ T cells are not essential for control of early acute Cryptosporidium parvum infection in neonatal mice.Infection and immunity · 2011Article
- Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates.Infection and immunity · 2010Article
- Purified PTP1 protein induces antigen-specific protective immunity against Encephalitozoon cuniculi.Microbes and infection · 2010Article
- Activation of protective cell-mediated immune response in gastric mucosa during Cryptosporidium muris infection and re-infection in immunocompetent mice.Parasitology research · 2010Article
- Human CD8(+) T cells clear Cryptosporidium parvum from infected intestinal epithelial cells.The American journal of tropical medicine and hygiene · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Resistance to and control of Cryptosporidium parvum infection in mice in the absence of adaptive immunity appears to be gamma interferon (IFN-gamma) dependent. Using an IFN-gamma-neutralizing antibody in a murine model, we demonstrated increased susceptibility to infection within 24 h. We correlated this early resistance and control with increased mucosal expression of IFN-gamma and demonstrate that CD8+ T-cell receptor alphabeta intestinal intraepithelial lymphocytes express and secrete this cytokine shortly after infection. The rapid kinetics of IFN-gamma expression and secretion by naive CD8+ T cells in response to a protozoan pathogen have not previously been demonstrated.
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Registered trials
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