ArticleInfection and immunity2005
Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Models for Inducing Experimental Cryptococcosis in Mice.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Editorial: Exploring novel experimental systems to study the mechanistic basis of fungal infections.Frontiers in fungal biology · 2023Article
- Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections.BMC microbiology · 2022Article
- Infections ofFrontiers in cellular and infection microbiology · 2022Article
- Comprehensive genetic analysis of adhesin proteins and their role in virulence of Candida albicans.Genetics · 2021Article
- The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells.Scientific reports · 2021Article
- The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Review
- NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.Infection and immunity · 2020Article
- Caenorhabditis elegans as a model animal for investigating fungal pathogenesis.Medical microbiology and immunology · 2020Review
- Review
- Article
- A multi-host approach for the systematic analysis of virulence factors in Cryptococcus neoformans.The Journal of infectious diseases · 2015Article
- Live and dead GFP-tagged bacteria showed indistinguishable fluorescence in Caenorhabditis elegans gut.Journal of microbiology (Seoul, Korea) · 2013Article
- Galleria mellonella as a model host to study Paracoccidioides lutzii and Histoplasma capsulatum.Virulence · 2013Article
- Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.The American journal of pathology · 2012Article
- The role of mycelium production and a MAPK-mediated immune response in the C. elegans-Fusarium model system.Medical mycology · 2012Article
- Caenorhabditis elegans, a model organism for investigating immunity.Applied and environmental microbiology · 2012Review
- Selecting an invertebrate model host for the study of fungal pathogenesis.PLoS pathogens · 2012Article
- DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Caenorhabditis elegans can serve as a substitute host for the study of microbial pathogenesis. We found that mutations in genes of the fungal pathogen Cryptococcus neoformans involved in mammalian virulence allow C. elegans to produce greater numbers of progeny than when exposed to wild-type fungus. We used this property to screen a library of C. neoformans mutants for strains that permit larger C. elegans brood sizes. In this screen, we identified a gene homologous to Saccharomyces cerevisiae ROM2. C. neoformans rom2 mutation resulted in a defect in mating and growth defects at elevated temperature or in the presence of cell wall or hyperosmolar stresses. An effect of the C. neoformans rom2 mutation in virulence was confirmed in a murine inhalation infection model. We propose that a screen for progeny-permissive mutants of microorganisms can serve as a high-throughput method for identifying novel loci related to mammalian pathogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.