ArticleInfection and immunity2005
Chronic Leishmania donovani infection promotes bystander CD8+-T-cell expansion and heterologous immunity.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model ofFrontiers in immunology · 2025Article
- Early Leukocyte Responses inFrontiers in cellular and infection microbiology · 2021Article
- Cytokines and splenic remodelling duringCytokine: X · 2020Article
- Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling.Frontiers in immunology · 2018Article
- Regulation of immunity during visceral Leishmania infection.Parasites & vectors · 2016Review
- Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection.PLoS pathogens · 2014Article
- CD8 T cell exhaustion in human visceral leishmaniasis.The Journal of infectious diseases · 2014Article
- Chronic bystander infections and immunity to unrelated antigens.Cell host & microbe · 2012Review
- Immunobiology of visceral leishmaniasis.Frontiers in immunology · 2012Article
- Leishmaniasis: complexity at the host-pathogen interface.Nature reviews. Microbiology · 2011Review
- Heterologous immunity: immunopathology, autoimmunity and protection during viral infections.Autoimmunity · 2011Review
- Heterologous immunity between viruses.Immunological reviews · 2010Review
- Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
It has been proposed that long-lived memory T cells generated by vaccination or infection reside within a memory compartment that has a finite size. Consequently, in a variety of acute infection models interclonal competition has been shown to lead to attrition of preexisting memory CD8+ T cells. Contrary to expectations, therefore, we found that chronic Leishmania donovani infection of Listeria-immune mice results in heightened protection against subsequent Listeria challenge. This protection was associated with bystander expansion of Listeria-specific CD8+ T cells and a bias in these cells toward a central memory T-cell phenotype with an enhanced capacity for gamma interferon production. We propose that splenomegaly, which is characteristic of visceral leishmaniasis and other tropical infections, may help promote heterologous immunity by resetting the size of the memory compartment during chronic infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.