Trial reportThorax2005
Randomised controlled trial of non-invasive ventilation (NIV) for nocturnal hypoventilation in neuromuscular and chest wall disease patients with daytime normocapnia.
Trial report in Thorax, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02683772 (The Evaluation of the Astral VAPS AutoEPAP Treatment Algorithm), which is not on this map. Cited by 81 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of the Astral VAPS AutoEPAP Treatment Algorithm
Who cites it
81 citing papers in PubMed, 7 syntheses or guidelines pooled it, 434 citations in OpenAlex.
- Sleep disordered breathing in spinal cord injury: A systematic review.The journal of spinal cord medicine · 2016Pooled it
- Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders.The Cochrane database of systematic reviews · 2014Pooled it
- Non-pharmaceutical management of respiratory morbidity in children with severe global developmental delay.The Cochrane database of systematic reviews · 2014Pooled it
- Brazilian recommendations of mechanical ventilation 2013. Part 2.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2014Guideline
- Consensus statement on standard of care for congenital muscular dystrophies.Journal of child neurology · 2010Guideline
- Best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (NPPV) in stable chronic alveolar hypoventilation syndromes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2010Guideline
- Home mechanical ventilation: a Canadian Thoracic Society clinical practice guideline.Canadian respiratory journalGuideline
- Impact of Early Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A multicenter Randomized Controlled Trial.Journal of neuromuscular diseases · 2023Trial
- Integrated Care Intervention Supported by a Mobile Health Tool for Patients Using Noninvasive Ventilation at Home: Randomized Controlled Trial.JMIR mHealth and uHealth · 2020Trial
- Trial
- The Role of Sleep Studies to Predict Post-Operative Outcomes in Children with Medical Complexity.Children (Basel, Switzerland) · 2026Article
- Severe sleep-related hypoventilation in antibody-positive and antibody-negative autoimmune encephalitis: an emergency.The European respiratory journal · 2026Article
- The role of sleep-disordered breathing in adolescents with spinal muscular atrophy.Sleep & breathing = Schlaf & Atmung · 2026Review
- Detection of nocturnal desaturation and hypercapnia using accelerometer-integrated pulse oximetry: a prospective observational study.Respiratory research · 2026Observational
- Current Standards and Future Directions of Duchenne Muscular Dystrophy Respiratory Care: The PPMD Italy Meeting Report.Pediatric pulmonology · 2025Article
- Multiple respiratory assessment and thresholds for noninvasive ventilation in adult patients with spinal muscular atrophy.Scientific reports · 2025Article
- Rehabilitation Strategies for Patients With Spinal Muscular Atrophy in the Era of Disease-Modifying Therapy.Annals of rehabilitation medicine · 2024Article
- The Role of Obstructive Sleep Apnea in Hypercapnic Respiratory Failure Identified in Critical Care, Inpatient, and Outpatient Settings.Sleep medicine clinics · 2024Review
- Enhancing respiratory function in neuromuscular disease: the role of non-invasive ventilation. A narrative review.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2024Review
- Update in Noninvasive Home Mechanical Ventilation: A Narrative Review of Indications, Outcomes, and Monitoring.Canadian respiratory journal · 2024Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong term non-invasive ventilation (NIV) reduces morbidity and mortality in patients with neuromuscular and chest wall disease with hypercapnic ventilatory failure, but preventive use has not produced benefit in normocapnic patients with Duchenne muscular dystrophy. Individuals with nocturnal hypercapnia but daytime normocapnia were randomised to a control group or nocturnal NIV to examine whether nocturnal hypoventilation is a valid indication for NIV.
methodsForty eight patients with congenital neuromuscular or chest wall disease aged 7-51 years and vital capacity<50% predicted underwent overnight respiratory monitoring. Twenty six with daytime normocapnia and nocturnal hypercapnia were randomised to either nocturnal NIV or to a control group without ventilatory support. NIV was started in the control group if patients fulfilled preset safety criteria.
resultsPeak nocturnal transcutaneous carbon dioxide tension (Tcco2) did not differ between the groups, but the mean (SD) percentage of the night during which Tcco2 was >6.5 kPa decreased in the NIV group (-57.7 (26.1)%) but not in controls (-11.75 (46.1)%; p=0.049, 95% CI -91.5 to -0.35). Mean (SD) arterial oxygen saturation increased in the NIV group (+2.97 (2.57)%) but not in controls (-1.12 (2.02)%; p=0.024, 95% CI 0.69 to 7.5). Nine of the 10 controls failed non-intervention by fulfilling criteria to initiate NIV after a mean (SD) of 8.3 (7.3) months.
conclusionPatients with neuromuscular disease with nocturnal hypoventilation are likely to deteriorate with the development of daytime hypercapnia and/or progressive symptoms within 2 years and may benefit from the introduction of nocturnal NIV before daytime hypercapnia ensues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.