ArticleBiophysical journal2006
Cell population dynamics modulate the rates of tissue growth processes.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effects of cell seeding technique and cell density on BMP-2 production in transduced human mesenchymal stem cells.Journal of biomedical materials research. Part A · 2022Article
- Toward improvedAPL bioengineering · 2021Article
- Collective cell migration has distinct directionality and speed dynamics.Cellular and molecular life sciences : CMLS · 2017Article
- In silico characterization of cell-cell interactions using a cellular automata model of cell culture.BMC research notes · 2017Article
- A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering.Meccanica · 2017Article
- Investigating biocomplexity through the agent-based paradigm.Briefings in bioinformatics · 2015Review
- Adipose Stem Cell Coating of Biomimetic β-TCP Macrospheres by Use of Laboratory Centrifuge.BioResearch open access · 2013Article
- Article
- Sequentially pulsed fluid delivery to establish soluble gradients within a scalable microfluidic chamber array.Biomicrofluidics · 2013Article
- PLLA-collagen and PLLA-gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering.Science and technology of advanced materials · 2012Article
- Efficient coarse simulation of a growing avascular tumor.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- Article
- Keeping in touch with contact inhibition of locomotion.Trends in cell biology · 2010Review
- Rule-Based Simulation of Multi-Cellular Biological Systems-A Review of Modeling Techniques.Cellular and molecular bioengineering · 2009Article
- A 3D hybrid model for tissue growth: the interplay between cell population and mass transport dynamics.Biophysical journal · 2009Article
- Article
- Astroglial injury in an ex vivo model: contributions to its analysis in enriched cell cultures.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The development and testing of a discrete model describing the dynamic process of tissue growth in three-dimensional scaffolds is presented. The model considers populations of cells that execute persistent random walks on the computational grid, collide, and proliferate until they reach confluence. To isolate the effect of population dynamics on tissue growth, the model assumes that nutrient and growth factor concentrations remain constant in space and time. Simulations start either by distributing the seed cells uniformly and randomly throughout the scaffold, or from an initial condition designed to simulate the migration and cell proliferation phase of wound healing. Simulations with uniform seeding show that cell migration enhances tissue growth by counterbalancing the adverse effects of contact inhibition. This beneficial effect, however, diminishes and disappears completely for large migration speeds. By contrast, simulations with the "wound" seeding mode show a continual enhancement of tissue regeneration rates with increasing cell migration speeds. We conclude that cell locomotory parameters and the spatial distribution of seed cells can have profound effects on the dynamics of the process and, consequently, on the pattern and rates of tissue growth. These results can guide the design of experiments for testing the effectiveness of biomimetic modifications for stimulating tissue growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.