ArticleBiophysical journal2006
Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 166 citations in OpenAlex.
- Overcoming LPS-mediated resistance in gram-negative pathogens: a review of LL-37 analogs and computational design strategies.Archives of microbiology · 2026Review
- Serine protease HtrA promotesScience advances · 2026Article
- Surface Interactions between an Eco-Friendly Antifouling Agent andACS applied bio materials · 2026Article
- Effects of Surface Charge of Amphiphilic Peptides on Peptide-Lipid Interactions in the Gas Phase and in Solution.Analytical chemistry · 2025Article
- Thermodynamic Study on BiomimeticMolecules (Basel, Switzerland) · 2024Article
- Chirality and pH Influence the Self-Assembly of Antimicrobial Lipopeptides with Diverse Nanostructures.ACS applied bio materials · 2024Article
- Interactions of Brominated Flame Retardants with Membrane Models of Dehalogenating Bacteria: Langmuir Monolayer and Grazing Incidence X-ray Diffraction Studies.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Neural network analysis of neutron and X-ray reflectivity data incorporating prior knowledge.Journal of applied crystallography · 2024Article
- Susceptibility ofMolecules (Basel, Switzerland) · 2024Article
- Recent advances in the therapeutic potential of cathelicidins.Frontiers in microbiology · 2024Review
- Deciphering Solution and Gas-Phase Interactions between Peptides and Lipids by Native Mass Spectrometry.Analytical chemistry · 2023Article
- Effects of synthetic peptide RP557 and its origin, LL-37, on carbapenem-resistantMicrobiology spectrum · 2023Article
- Insight into the Mechanism of Interactions between the LL-37 Peptide and Model Membranes ofInternational journal of molecular sciences · 2023Article
- Photoinduced bidirectional switching in lipid membranes containing azobenzene glycolipids.Scientific reports · 2023Article
- Design, synthesis, and characterization of non-hemolytic antimicrobial peptides related to human cathelicidin LL-37.RSC advances · 2023Article
- Development of a Novel Antibacterial Peptide, PAM-5, via Combination of Phage Display Selection and Computer-Assisted Modification.Biomolecules · 2023Article
- Neural network analysis of neutron and X-ray reflectivity data: automated analysis usingJournal of applied crystallography · 2022Article
- Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures.International journal of molecular sciences · 2021Review
- Interruption of the tricarboxylic acid cycle inAIMS microbiology · 2021Article
- Cooperative Function of LL-37 and HNP1 Protects Mammalian Cell Membranes from Lysis.Biophysical journal · 2020Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interaction of the human antimicrobial peptide LL-37 with lipid monolayers has been investigated by a range of complementary techniques including pressure-area isotherms, insertion assay, epifluorescence microscopy, and synchrotron x-ray scattering, to analyze its mechanism of action. Lipid monolayers were formed at the air-liquid interface to mimic the surface of the bacterial cell wall and the outer leaflet of erythrocyte cell membrane by using phosphatidylglycerol (DPPG), phosphatidylcholine (DPPC), and phosphatidylethanolamine (DPPE) lipids. LL-37 is found to readily insert into DPPG monolayers, disrupting their structure and thus indicating bactericidal action. In contrast, DPPC and DPPE monolayers remained virtually unaffected by LL-37, demonstrating its nonhemolytic activity and lipid discrimination. Specular x-ray reflectivity data yielded considerable differences in layer thickness and electron-density profile after addition of the peptide to DPPG monolayers, but little change was seen after peptide injection when probing monolayers composed of DPPC and DPPE. Grazing incidence x-ray diffraction demonstrated significant peptide insertion and lateral packing order disruption of the DPPG monolayer by LL-37 insertion. Epifluorescence microscopy data support these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.