ArticleNeurotoxicology and teratology
Dysmorphic and anthropometric outcomes in 6-year-old prenatally cocaine-exposed children.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations.JAMA pediatrics · 2020Article
- An Ecodevelopmental Exploration of Mediators Between Maltreatment in Childhood and Drug use During Pregnancy.Merrill-Palmer quarterly (Wayne State University. Press) · 2017Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Review
- Developmental and behavioral consequences of prenatal cocaine exposure: a review.Journal of perinatology : official journal of the California Perinatal Association · 2012Review
- The effects of prenatal methamphetamine exposure on childhood growth patterns from birth to 3 years of age.American journal of perinatology · 2012Article
- Prenatal tobacco, marijuana, stimulant, and opiate exposure: outcomes and practice implications.Addiction science & clinical practice · 2011Review
- Potential latent effects of prenatal cocaine exposure on growth and the risk of cardiovascular and metabolic disease in childhood.Progress in pediatric cardiology · 2011Article
- Review
- Prenatal cocaine exposure and childhood obesity at nine years.Neurotoxicology and teratologyArticle
- Effects of prenatal cocaine exposure on child behavior and growth at 10 years of age.Neurotoxicology and teratologyArticle
- Prenatal cocaine exposure and small-for-gestational-age status: effects on growth at 6 years of age.Neurotoxicology and teratologyArticle
- Effects of prenatal cocaine exposure on pubertal development.Neurotoxicology and teratologyArticle
- Effects of prenatal cocaine exposure on adolescent development.Neurotoxicology and teratologyArticle
- Preadolescent behavior problems after prenatal cocaine exposure: Relationship between teacher and caretaker ratings (Maternal Lifestyle Study).Neurotoxicology and teratologyArticle
- Prenatal cocaine exposure: Effects on mother- and teacher-rated behavior problems and growth in school-age children.Neurotoxicology and teratologyArticle
- Pre-natal exposures to cocaine and alcohol and physical growth patterns to age 8 years.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Dysmorphologic and anthropometric assessments were performed on 154 6-year-old children prenatally exposed to cocaine (PCE) and 131 high-risk controls (NCE) of similar race and social class. Adjusted mean height z scores demonstrated a dose-response with metahydroxybenzoylecgonine above a threshold of 100 ng/g of meconium and greater cocaine exposure predicted lower weight for height z score. Higher average alcohol exposure throughout pregnancy and 3rd trimester predicted lower head circumference and weight z scores, respectively. Severity of marijuana use also predicted lower height for age but greater weight for height. There was not an increased rate of minor anomalies among the PCE cohort, nor was a consistent phenotype identified. After controlling for covariates, higher average prenatal cigarette exposure predicted higher incidence of cranial facial abnormalities. First trimester alcohol exposure predicted greater rates of ear abnormalities and third trimester marijuana exposure predicted greater rates of chest and head shape abnormalities. These finding indicate that prenatal cocaine exposure has a negative effect on specific growth outcomes including standardized height and weight for height, but not a systematic pattern of structural abnormalities.
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